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Andrea Mainardi
Researcher at Polytechnic University of Milan
Publications - 8
Citations - 160
Andrea Mainardi is an academic researcher from Polytechnic University of Milan. The author has contributed to research in topics: Computer science & Organ-on-a-chip. The author has an hindex of 2, co-authored 5 publications receiving 75 citations. Previous affiliations of Andrea Mainardi include University of Basel & University Hospital of Basel.
Papers
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Journal ArticleDOI
Hyperphysiological compression of articular cartilage induces an osteoarthritic phenotype in a cartilage-on-a-chip model
Paola Occhetta,Andrea Mainardi,Andrea Mainardi,Andrea Mainardi,Emiliano Votta,Queralt Vallmajo-Martin,Martin Ehrbar,Ivan Martin,Ivan Martin,Andrea Barbero,Marco Rasponi +10 more
TL;DR: This work shows, using a newly developed microphysiological cartilage-on-a-chip model that enables the application of strain-controlled compression to three-dimensional articular cartilage microtissue, that a 30% confined compression recapitulates the mechanical factors involved in OA pathogenesis and is sufficient to induce OA traits.
Book ChapterDOI
Generation of functional cardiac microtissues in a beating heart-on-a-chip.
TL;DR: The fabrication and operation procedures for a beating heart-on-a-chip is described, which features a culture region for a 3D cardiac microtissue and a system for applying tuned mechanical stimulation during culture to improve cardiac development.
Journal ArticleDOI
A dynamic microscale mid-throughput fibrosis model to investigate the effects of different ratios of cardiomyocytes and fibroblasts.
Andrea Mainardi,Andrea Mainardi,Andrea Mainardi,Francesca Giulia Carminati,Francesca Giulia Carminati,Giovanni Stefano Ugolini,Paola Occhetta,Giuseppe Isu,Diana Robles Diaz,Gregory Reid,Gregory Reid,Roberta Visone,Marco Rasponi,Anna Marsano +13 more
TL;DR: In this article, a microphysiological system (MPS) was used to co-culture different ratios of activated fibroblasts (FBs) and cardiomyocytes (CMs) in a mechanically active, three-dimensional (3D) environment.
Journal ArticleDOI
Intervertebral Disc-on-a-Chip as Advanced In Vitro Model for Mechanobiology Research and Drug Testing: A Review and Perspective
Andrea Mainardi,Elena Cambria,Paola Occhetta,Ivan Martin,Andrea Barbero,Stefan Schären,Arne Mehrkens,Olga Krupková +7 more
TL;DR: This review analyzes and depicts existing OoC platforms used to investigate pathological alterations of IVD cells/tissues, and proposes the view on design criteria for IVD-on-a-chip systems, offering a future perspective to model IVD mechanobiology.
Journal ArticleDOI
Chondrocyte Hypertrophy in Osteoarthritis: Mechanistic Studies and Models for the Identification of New Therapeutic Strategies
Shikha Chawla,Andrea Mainardi,Nilotpal Majumder,Laura Dönges,B Deepak Kumar,Paola Occhetta,Ivan Martin,Christian Egloff,Sourabh Ghosh,Amitabha Bandyopadhyay,Andrea Barbero +10 more
TL;DR: In this paper , the authors highlight the possible advantages and drawbacks of using this approach as a therapeutic strategy while focusing on the experimental models necessary for a better understanding of the phenomenon, suggesting potential disease-modifying therapeutic approaches.