Andrea Tannapfel

TL;DR: Findings from the phase 2 part of the FLOT4 trial, which compared histopathological regression in patients treated with a docetaxel-based triplet chemotherapy versus an anthracycline-based doublet chemotherapy before surgical resection, suggest FLOT was associated with significantly higher proportions of patients achieving pathological complete regression than was ECF/ECX.

TL;DR: Results show that miR-34 inactivation is a common event in tumor formation, and suggest that CpG methylation of miR_34a and miR/c may have diagnostic value, and mutual exclusiveness of mi R-34a methylation and p53 mutation indicates thatmiR- 34a inactivation may substitute for loss of p53 function in cancer.

TL;DR: Authors M. Moehler, S-E.

TL;DR: This study is the first to evaluate the diagnostic potential of miRNAs in a clinical setting and has shown that miRNA analysis of pancreatic FNA biopsy samples can aid in the pathologic evaluation of suspicious cases and may provide a new strategy for improving the diagnosis of Pancic diseases.

TL;DR: This open-label, non-inferiority, randomised phase 3 trial investigated whether no continuation of therapy or bevacizumab alone are non- inferior to fluoropyrimidine plus bevacsumab, following induction treatment with a fluoropyridine plus oxaliplatin plus beVacizumsab.