Revisions to the staging and classification of mycosis fungoides and Sezary syndrome: a proposal of the International Society for Cutaneous Lymphomas (ISCL) and the cutaneous lymphoma task force of the European Organization of Research and Treatment of Cancer (EORTC).

Mycosis fungoides (MF) and Sezary syndrome (SS), the major forms of cutaneous T-cell lymphoma, have unique characteristics that distinguish them from other types of non-Hodgkin's lymphomas. Clinical trials in MF/SS have suffered from a lack of standardization in evaluation, staging, assessment, end points, and response criteria. Recently defined criteria for the diagnosis of early MF, guidelines for initial evaluation, and revised staging and classification criteria for MF and SS now offer the potential for uniform staging of patients enrolled in clinical trials for MF/SS. This article presents consensus recommendations for the general conduct of clinical trials of patients with MF/SS as well as methods for standardized assessment of potential disease manifestations in skin, lymph nodes, blood, and visceral organs, and definition of end points and response criteria. These guidelines should facilitate collaboration among investigators and collation of data from sponsor-generated or investigator-initiated c...

Clinical end points and response criteria in mycosis fungoides and Sézary syndrome: a consensus statement of the International Society for Cutaneous Lymphomas, the United States Cutaneous Lymphoma Consortium, and the Cutaneous Lymphoma Task Force of the European Organisation for Research and Treatment of Cancer.

EORTC consensus recommendations for the treatment of mycosis fungoides/Sézary syndrome.

/pdf/nccn-clinical-practice-guidelines-in-oncology-non-hodgkin-s-33udgooyoh.pdf

NCCN Clinical Practice Guidelines in Oncology: non-Hodgkin's lymphomas.

The new WHO/EORTC classification for cutaneous lymphomas
comprises mature T-cell and natural killer (NK)-cell neoplasms,
mature B-cell neoplasms, and immature hematopoietic
malignancies. It reflects the unique features of
lymphoproliferative diseases of the skin, and at the same time
it is as compatible as possible with the concepts underlying
the WHO classification for nodal lymphomas and the EORTC
classification of cutaneous lymphomas. This article reviews the
histological, phenotypical, and molecular genetic features of
the various nosological entities included in this new
classification. These findings always have to be interpreted in
the context of the clinical features and biologic behavior

/pdf/who-eortc-classification-of-cutaneous-lymphomas-2005-347bvs9tze.pdf

WHO/EORTC classification of cutaneous lymphomas 2005: histological and molecular aspects.

This editorial review summarizes the results of 5 meetings sponsored by the International Society for Cutaneous Lymphoma at which the clinicopathologic and ancillary features of early mycosis fungoides were critically examined. Based on this analysis, an algorithm was developed for the diagnosis of early mycosis fungoides involving a holistic integration of clinical, histopathologic, immunopathologic, and molecular biological characteristics. A novel aspect of this algorithm is that it relies on multiple types of criteria rather than just one, for example, histopathology. Before its finalization, the proposed diagnostic algorithm will require validation and possibly further refinement at multiple centers during the next several years. It is anticipated that a more standardized approach to the diagnosis of early mycosis fungoides will have a beneficial impact on the epidemiology, prognostication, treatment, and analysis of clinical trials pertaining to this most common type of cutaneous lymphoma.

https://flore.unifi.it/bitstream/2158/311708/1/Defining%20early%20mycosis%20fungoides.pdf

Defining early mycosis fungoides.

Large areas of sub-Saharan Africa suffer a substantial lack of skin care. Hence teledermatology, meaning the online visual exchange of clinical and histologic data, could develop into a powerful medical resource. We report the first established teledermatologic connection in this area: between the Regional Dermatology Training Centre (RDTC) in Moshi, Northern Tanzania, and the Department of Dermatology, University Hospital of Zurich, Switzerland. This report illustrates local difficulties as well as the considerable potential of teledermatology in such a setting.

https://www.jaad.org/article/S0190-9622(00)70042-9/pdf

Andreas C. Haeffner

Papers

Defining early mycosis fungoides.

Teledermatology as a new tool in sub-saharan Africa: an experience from Tanzania.