Showing papers by "Andreas L. Birkenfeld published in 2006"
TL;DR: In this paper, the authors determined the metabolic and cardiovascular interaction of β-adrenergic receptors and atrial natriuretic peptide (ANP) in a crossover study, conducted at an academic clinical research center.
Abstract: Context: Atrial natriuretic peptide (ANP) has well-known cardiovascular effects and modifies lipid and carbohydrate metabolism in humans Objective: The objective of the study was to determine the metabolic and cardiovascular interaction of β-adrenergic receptors and ANP Design: This was a crossover study, conducted 2004–2005 Setting: The study was conducted at an academic clinical research center Patients: Patients included 10 healthy young male subjects (body mass index 24 ± 1 kg/m2) Intervention: We infused iv incremental ANP doses (625, 125, and 25 ng/kg·min) with and without propranolol (020 mg/kg in divided doses followed by 0033 mg/kg·h infusion) Metabolism was monitored through venous blood sampling, im, and sc microdialysis and indirect calorimetry Cardiovascular changes were monitored by continuous electrocardiogram and beat-by-beat blood pressure recordings Main Outcome Measures: Venous nonesterified fatty acid, glycerol, glucose, and insulin; and microdialysate glucose, glycerol, la
51 citations
TL;DR: In healthy subjects, NET inhibition prevents tilt-induced neurally mediated (pre)syncope, and may be a worthwhile target of drug intervention for larger trials in highly symptomatic patients with neurallymediated syncope.
44 citations