A
Andreas W. Jehle
Researcher at University Hospital of Basel
Publications - 22
Citations - 472
Andreas W. Jehle is an academic researcher from University Hospital of Basel. The author has contributed to research in topics: Podocyte & Palmitic acid. The author has an hindex of 8, co-authored 18 publications receiving 391 citations. Previous affiliations of Andreas W. Jehle include University of Basel.
Papers
More filters
Journal ArticleDOI
Regulation of podocyte survival and endoplasmic reticulum stress by fatty acids
Jonas Sieber,Maja T. Lindenmeyer,Kapil Kampe,Kirk N. Campbell,Clemens D. Cohen,Helmut Hopfer,Peter Mundel,Andreas W. Jehle,Andreas W. Jehle +8 more
TL;DR: It is shown that palmitic acid increases podocyte cell death, both apoptosis and necrosis of podocytes, in a dose and time-dependent fashion and offers a rationale for interventional studies aimed at testing whether dietary shifting of the FFA balance toward unsaturated FFAs can delay the progression of DN.
Journal ArticleDOI
Free Fatty acids and their metabolism affect function and survival of podocytes.
Jonas Sieber,Andreas W. Jehle +1 more
TL;DR: The opposing effects of saturated and monounsaturated FFAs are outlined and a particular emphasis will be given to the underlying molecular mechanisms involving insulin resistance and endoplasmic reticulum homeostasis.
Journal ArticleDOI
Acute Renal Failure on Immune Reconstitution in an HIV-Positive Patient with Miliary Tuberculosis
Andreas W. Jehle,Nina Khanna,Jörg-Peter Sigle,Katharina Glatz-Krieger,Manuel Battegay,Jürg Steiger,Michael Dickenmann,Hans H. Hirsch +7 more
TL;DR: The diagnostic workup and further course of disease implicated immune reconstitution syndrome as the cause of acute renal failure in a patient with miliary tuberculosis and urinary shedding of acid fast bacilli.
Journal ArticleDOI
Angiotensin II induces interleukin-1β-mediated islet inflammation and β-cell dysfunction independently of vasoconstrictive effects.
Nadine S. Sauter,Constanze Thienel,Constanze Thienel,Yuliya Plutino,Kapil Kampe,Erez Dror,Erez Dror,Shuyang Traub,Shuyang Traub,Katharina Timper,Katharina Timper,Benoît Bédat,François Pattou,Julie Kerr-Conte,Andreas W. Jehle,Marianne Böni-Schnetzler,Marianne Böni-Schnetzler,Marc Y. Donath,Marc Y. Donath +18 more
TL;DR: It is concluded that angiotensin II leads to islet dysfunction via induction of inflammation and independent of vasoconstriction, revealing a novel role for the RAS and an additional rationale for the treatment of type 2 diabetic patients with an IL-1β antagonist.
Journal ArticleDOI
Susceptibility of podocytes to palmitic acid is regulated by fatty acid oxidation and inversely depends on acetyl-CoA carboxylases 1 and 2
TL;DR: In this article, the authors showed that the activation of low-energy sensor AMP-activated protein kinase (AMPK) was associated with a reduction of endoplasmic reticulum (ER) stress.