C
Clemens D. Cohen
Researcher at Ludwig Maximilian University of Munich
Publications - 162
Citations - 12012
Clemens D. Cohen is an academic researcher from Ludwig Maximilian University of Munich. The author has contributed to research in topics: Podocyte & Kidney. The author has an hindex of 57, co-authored 157 publications receiving 10545 citations. Previous affiliations of Clemens D. Cohen include Federal University of São Paulo & University of Zurich.
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Journal ArticleDOI
Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition
Debra F. Higgins,Kuniko Kimura,Wanja M. Bernhardt,Nikita Shrimanker,Yasuhiro Akai,Bernd Hohenstein,Yoshihiko Saito,Randall S. Johnson,Matthias Kretzler,Clemens D. Cohen,Kai-Uwe Eckardt,Masayuki Iwano,Volker H. Haase +12 more
TL;DR: Clinical and genetic evidence is provided that activation of HIF-1 signaling in renal epithelial cells is associated with the development of chronic renal disease and may promote fibrogenesis by increasing expression of extracellular matrix-modifying factors and lysyl oxidase genes and by facilitating EMT.
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Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice
Björn Hartleben,Markus Gödel,Catherine Meyer-Schwesinger,Shuya Liu,Theresa Ulrich,Sven Köbler,Thorsten Wiech,Florian Grahammer,Sebastian J. Arnold,Maja T. Lindenmeyer,Clemens D. Cohen,Hermann Pavenstädt,Dontscho Kerjaschki,Noboru Mizushima,Andrey S. Shaw,Gerd Walz,Tobias B. Huber +16 more
TL;DR: It is postulate that constitutive and induced autophagy is a major protective mechanism against podocyte aging and glomerular injury, representing a putative target to ameliorate human glomersular disease and aging-related loss of renal function.
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Role of mTOR in podocyte function and diabetic nephropathy in humans and mice
Markus Gödel,Björn Hartleben,Nadja Herbach,Shuya Liu,Stefan Zschiedrich,Shun Lu,Andrea Debreczeni-Mór,Maja T. Lindenmeyer,Maria Pia Rastaldi,Götz Hartleben,Thorsten Wiech,Alessia Fornoni,Robert G. Nelson,Matthias Kretzler,Rüdiger Wanke,Hermann Pavenstädt,Dontscho Kerjaschki,Clemens D. Cohen,Michael N. Hall,Markus A. Rüegg,Ken Inoki,Gerd Walz,Tobias B. Huber,Tobias B. Huber +23 more
TL;DR: It is suggested that mTOR inhibition can protect podocytes and prevent progressive diabetic nephropathy and demonstrate the requirement for tightly balanced mTOR activity in podocyte homeostasis.
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Metabolomics Reveals Signature of Mitochondrial Dysfunction in Diabetic Kidney Disease
Kumar Sharma,Bethany Karl,Anna V. Mathew,Jon A. Gangoiti,Christina L. Wassel,Rintaro Saito,Minya Pu,Shoba Sharma,Young Hyun You,Lin Wang,Maggie Diamond-Stanic,Maja T. Lindenmeyer,Carol Forsblom,Wei Wu,Joachim H. Ix,Trey Ideker,Jeffrey B. Kopp,Sanjay K. Nigam,Clemens D. Cohen,Per-Henrik Groop,Per-Henrik Groop,Bruce A. Barshop,Loki Natarajan,William L. Nyhan,Robert K. Naviaux +24 more
TL;DR: It is concluded that urine metabolomics is a reliable source for biomarkers of diabetic complications, and the data suggest that renal organic ion transport and mitochondrial function are dysregulated in diabetic kidney disease.
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Modular Activation of Nuclear Factor-κB Transcriptional Programs in Human Diabetic Nephropathy
Holger Schmid,Anissa Boucherot,Anissa Boucherot,Yoshinari Yasuda,Anna Henger,Anna Henger,Bodo Brunner,Felix Eichinger,Felix Eichinger,Almut Nitsche,Eva Kiss,Markus Bleich,Hermann Josef Gröne,Peter J. Nelson,Detlef Schlöndorff,Clemens D. Cohen,Matthias Kretzler,Matthias Kretzler +17 more
TL;DR: The identification of a specific NF-κB promoter module activated in the inflammatory stress response of progressive DN has helped to characterize upstream pathways as potential targets for the treatment of progressive renal diseases such as DN.