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Andrei Kuzminov
Researcher at University of Illinois at Urbana–Champaign
Publications - 70
Citations - 3844
Andrei Kuzminov is an academic researcher from University of Illinois at Urbana–Champaign. The author has contributed to research in topics: DNA replication & DNA. The author has an hindex of 26, co-authored 66 publications receiving 3521 citations. Previous affiliations of Andrei Kuzminov include University of Oregon.
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Recombinational Repair of DNA Damage in Escherichia coli and Bacteriophage λ
TL;DR: It is now appreciated that DNA repair and homologous recombination are related through DNA replication, and knowledge about recombinational repair in the broader context of DNA replication will guide future experimentation.
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Single-strand interruptions in replicating chromosomes cause double-strand breaks
TL;DR: To model replication fork collapse in vivo, phage λ chromosomes carrying the nicking site of M13 bacteriophage are constructed and infected with these substrates Escherichia coli cells, producing M13 nicking enzyme and double-strand breaks at the nicks sites are detected.
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Collapse and repair of replication forks in Escherichia coli
TL;DR: A model for the repair of collapsed replication forks in Escherichia coli by the RecBCD recombinational pathway is proposed and schemes for various repeat‐mediated recombinational events are offered.
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DNA replication meets genetic exchange: chromosomal damage and its repair by homologous recombination.
TL;DR: Findings in experimental systems substantiate the idea that homologous recombination is a system supporting DNA replication when either the template DNA is damaged or the replication machinery malfunctions and suggest a bigger role for single-strand annealing in the eukaryotic recombinational repair.
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Chi sites in combination with RecA protein increase the survival of linear DNA in Escherichia coli by inactivating exoV activity of RecBCD nuclease.
TL;DR: It is shown that after terminase has cut cos in vivo, nucleases degrade linearized DNA only from the end that does not have a strong terminase binding site, which means linearized cosmid DNA containing chi sites in the proper orientation to the unprotected end is degraded more slowly in rec+ E. coli than is chi‐less DNA.