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Andres Hilfiker
Researcher at Emory University
Publications - 3
Citations - 498
Andres Hilfiker is an academic researcher from Emory University. The author has contributed to research in topics: Dosage compensation & Gene. The author has an hindex of 3, co-authored 3 publications receiving 481 citations.
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mof, a putative acetyl transferase gene related to the Tip60 and MOZ human genes and to the SAS genes of yeast, is required for dosage compensation in Drosophila
TL;DR: Experimental results and sequence analysis suggest that an additional gene, males‐absent on the first (mof), encodes a putative acetyl transferase that plays a direct role in the specific histone acetylation associated with dosage compensation.
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Dosage compensation in Drosophila: the X-chromosomal binding of MSL-1 and MLE is dependent on Sxl activity.
TL;DR: The association of these two msl gene products with the two X chromosomes in females of certain mutant genotypes does not result in the hypertranscription of X‐linked genes or in any apparent reduction in viability, and it is found that these gene products contribute to the formation of a multi‐subunit complex.
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Dosage compensation in Drosophila: the X chromosome binding of MSL-1 and MSL-2 in female embryos is prevented by the early expression of the Sxl gene
TL;DR: It is determined that the SXL made by the early promoter inhibits the hypertranscription of run at the blastoderm stage, and severe disturbances in SXL function result in lethality during embryogenesis while loss of msl function kills males much later.