J
John C. Lucchesi
Researcher at Emory University
Publications - 60
Citations - 4762
John C. Lucchesi is an academic researcher from Emory University. The author has contributed to research in topics: Dosage compensation & MSL complex. The author has an hindex of 31, co-authored 59 publications receiving 4522 citations.
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mof, a putative acetyl transferase gene related to the Tip60 and MOZ human genes and to the SAS genes of yeast, is required for dosage compensation in Drosophila
TL;DR: Experimental results and sequence analysis suggest that an additional gene, males‐absent on the first (mof), encodes a putative acetyl transferase that plays a direct role in the specific histone acetylation associated with dosage compensation.
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RNA-mediated neurodegeneration caused by the fragile X premutation rCGG repeats in Drosophila.
Peng Jin,Daniela C. Zarnescu,Fuping Zhang,Christopher E. Pearson,John C. Lucchesi,Kevin Moses,Stephen T. Warren +6 more
TL;DR: It is demonstrated that neurodegenerative phenotype associated with fragile X premutation is indeed caused by the lengthened rCGG repeats and provided the first in vivo experimental demonstration of RNA-mediated neurodegenersation.
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The drosophila MSL complex acetylates histone H4 at lysine 16, a chromatin modification linked to dosage compensation.
Edwin R. Smith,Edwin R. Smith,Antonio Pannuti,Weigang Gu,Arnd Steurnagel,Richard G. Cook,C. David Allis,John C. Lucchesi +7 more
TL;DR: It is demonstrated that the MSL complex is responsible for the specific chromatin modification characteristic of the X chromosome in Drosophila males.
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ESA1 is a histone acetyltransferase that is essential for growth in yeast
Edwin R. Smith,Arri Eisen,Weigang Gu,Martin Sattah,Antonio Pannuti,Jianxin Zhou,Richard G. Cook,John C. Lucchesi,C D Allis +8 more
TL;DR: A yeast ORF with homology to MYST family members and show it possesses histone acetyltransferase activity is expressed and unlike the other MYSTfamily members in Saccharomyces cerevisiae this gene is essential for growth.
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A Human Protein Complex Homologous to the Drosophila MSL Complex Is Responsible for the Majority of Histone H4 Acetylation at Lysine 16
TL;DR: It is found that reduction in the levels of hMSLs and acetylation of H4 at lysine 16 are correlated with reduced transcription of some genes and with a G2/M cell cycle arrest.