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Andrew C. Good
Researcher at Bristol-Myers Squibb
Publications - 43
Citations - 1635
Andrew C. Good is an academic researcher from Bristol-Myers Squibb. The author has contributed to research in topics: Virtual screening & Hepatitis C virus. The author has an hindex of 20, co-authored 42 publications receiving 1566 citations. Previous affiliations of Andrew C. Good include Genzyme & University of Hertfordshire.
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Patent
Hepatitis C virus inhibitors
Carol Bachand,Makonen Belema,Deon Daniel H,Andrew C. Good,Goodrich Jason,James Clint A,Lavoie Rico,Lopez Omar D,Alain Martel,Nicholas A. Meanwell,Van N. Nguyen,Jeffrey L. Romine,Ruediger Edward H,Lawrence B. Snyder,Denis R. St. Laurent,Fukang Yang,David R. Langley,Gan Wang,Lawrence G. Hamann +18 more
TL;DR: The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection as mentioned in this paper, and also disclosed are pharmaceutical compositions containing such compounds and methods to use these compounds in the treatment.
Journal ArticleDOI
The Discovery of Asunaprevir (BMS-650032), An Orally Efficacious NS3 Protease Inhibitor for the Treatment of Hepatitis C Virus Infection
Paul Michael Scola,Li-Qiang Sun,Alan Xiangdong Wang,Jie Chen,Ny Sin,Brian Lee Venables,Sing-Yuen Sit,Yan Chen,Anthony J. Cocuzza,Bilder Donna M,Stanley D'andrea,Barbara Zheng,Piyasena Hewawasam,Yong Tu,Jacques Friborg,Paul Falk,Dennis Hernandez,Steven Levine,Chaoqun Chen,Fei Yu,Amy K. Sheaffer,Guangzhi Zhai,Diana Barry,Jay O. Knipe,Yong-Hae Han,Richard Schartman,Maria Donoso,Kathy Mosure,Michael Sinz,Tatyana Zvyaga,Andrew C. Good,Ramkumar Rajamani,Kevin Kish,Jeffrey Tredup,Herbert E. Klei,Qi Gao,Luciano Mueller,Richard J. Colonno,Dennis M. Grasela,Stephen P. Adams,James Loy,Paul Levesque,Huabin Sun,Hong Shi,Lucy Sun,William Warner,Danshi Li,Jialong Zhu,Nicholas A. Meanwell,Fiona McPhee +49 more
TL;DR: The structure-activity relationships (SARs) developed with respect to CV effects established that small structural changes to the P2* subsite of the molecule had a significant impact on the CV profile of a given compound.
Journal ArticleDOI
An empirical process for the design of high-throughput screening deck filters.
TL;DR: A process for objective identification and filtering of undesirable compounds that contribute to high-throughput screening (HTS) deck promiscuity is described and statistical evaluation of the data indicates a correlation between the resultant functional group filters and compound promiscuit.
Journal Article
Ranking poses in structure-based lead discovery and optimization: current trends in scoring function development.
Ramkumar Rajamani,Andrew C. Good +1 more
TL;DR: There is an abundance of new research in the field of scoring function design, from incorporation of novel descriptors (derived from first principles or empirical analysis) to function redesign based on improved data set handling.
Journal ArticleDOI
Measuring CAMD technique performance: a virtual screening case study in the design of validation experiments.
TL;DR: This work addresses the issue for ligand-based virtual screening descriptors through design of validation experiments that better reflect the aims of real world application and Guidelines for optimal application of said descriptors are discussed.