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James Loy

Researcher at Bristol-Myers Squibb

Publications -  18
Citations -  2709

James Loy is an academic researcher from Bristol-Myers Squibb. The author has contributed to research in topics: T cell & Chemokine. The author has an hindex of 13, co-authored 16 publications receiving 2581 citations.

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Journal ArticleDOI

Osteopetrosis in mice lacking NF-kappaB1 and NF-kappaB2.

Violetta Iotsova, +5 more
- 01 Nov 1997 - 
TL;DR: A new mouse osteopetrotic mutant is defined and NF-κB proteins in bone development are implicate, raising new directions in the treatment of bone disorders.
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Defects in Macrophage Recruitment and Host Defense in Mice Lacking the CCR2 Chemokine Receptor

Takao Kurihara, +3 more
- 17 Nov 1997 - 
TL;DR: CCR2 has a nonredundant role as a major mediator of macrophage recruitment and host defense against bacterial pathogens and that MCP-1 and other CCR2 ligands are effectors of those functions.
Journal Article

Impaired Macrophage Function and Enhanced T Cell-Dependent Immune Response in Mice Lacking CCR5, the Mouse Homologue of the Major HIV-1 Coreceptor

Yuhong Zhou, +7 more
- 15 Apr 1998 - 
TL;DR: A CCR5-deficient mouse model generated by targeted deletion of the ccr5 gene showed reduced efficiency in clearance of Listeria infection and exert a protective effect against LPS-induced endotoxemia, reflecting a partial defect in macrophage function.
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Dynamics of β-Amyloid Reductions in Brain, Cerebrospinal Fluid, and Plasma of β-Amyloid Precursor Protein Transgenic Mice Treated with a γ-Secretase Inhibitor

Donna M. Barten, +19 more
- 01 Feb 2005 - 
TL;DR: It is possible for γ-secretase inhibitors to reduce brain Aβ without causing Notch-mediated toxicity, and no changes in the maturation of CD8+ thymocytes or of intestinal goblet cells were observed in mice treated with BMS-299897.
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Neutrophil infiltration, glial reaction, and neurological disease in transgenic mice expressing the chemokine N51/KC in oligodendrocytes.

Marie Tani, +8 more
- 15 Jul 1996 - 
TL;DR: CNS-specific N51/KC expression produced remarkable neutrophil infiltration into perivascular, meningeal, and parenchymal sites, demonstrating that this chemokine exerts the multiple functions in vivo required to recruit leukocytes into the CNS.