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Andrew C. Lake
Researcher at Boston University
Publications - 2
Citations - 228
Andrew C. Lake is an academic researcher from Boston University. The author has contributed to research in topics: Acylation & Wild type. The author has an hindex of 2, co-authored 2 publications receiving 202 citations.
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Journal ArticleDOI
Plasmalogens as endogenous antioxidants: somatic cell mutants reveal the importance of the vinyl ether.
Raphael A. Zoeller,Andrew C. Lake,Narasimhan Nagan,Daniel P. Gaposchkin,Margaret A. Legner,Wilfred Lieberthal +5 more
TL;DR: The hypothesis that plasmalogens, through the vinyl ether, act as antioxidants to protect cells against ROS is supported and might protect cells from ROS-mediated damage during events such as chemical hypoxia.
Journal ArticleDOI
An animal cell mutant with a deficiency in acyl/alkyl-dihydroxyacetone-phosphate reductase activity. Effects on the biosynthesis of ether-linked and diacyl glycerolipids.
Paul F. James,Andrew C. Lake,Amiya K. Hajra,Leslie K. Larkins,Mitchell Robinson,F. Gregory Buchanan,Raphael A. Zoeller +6 more
TL;DR: The isolation of a series of mutants from the fibroblast-like cell line, CHO-K1, that are deficient in the incorporation of the long chain fatty alcohol, hexadecanol, into complex lipids suggest that the biosynthesis of diacyl phospholipids, in Chinese hamster ovary cells, begins with the acylation of dihydroxyacetone phosphate as well as glycero-3-phosphate and that the “DHAP pathway