Andrew C. Timmins

TL;DR: The use of dobutamine to boost the cardiac index and systemic oxygen delivery failed to improve the outcome in this heterogeneous group of critically ill patients, and it is suggested that in some cases aggressive efforts to increase oxygen consumption may have been detrimental.

TL;DR: In this article, a randomized trial was conducted to determine whether boosting oxygen delivery by infusing the inotropic agent dobutamine would improve the outcome in a diverse group of critically ill patients.

TL;DR: Critical illness is associated with low circulating concentrations of insulin-like growth factor-I, insulin- like growth factors-II, and insulin- Like growth factor binding protein 3 and these low values are associated with induction of protease activity specifically directed against insulin-Like growth factorbinding protein 3.

TL;DR: In this paper, the response to therapy aimed at achieving supranormal cardiac and oxygen transport variables (cardiac index [CI] >4.5 L/min/m 2, oxygen delivery [Do 2 ] >600 ml/min /m 2 ) in a heterogenous group of critically ill patients and to assess its relationship to outcome was evaluated.

TL;DR: Survivors of sepsis syndrome or septic shock are characterized by an ability to increase both DO2 andVO2, which may help to explain the findings by some investigators that treatment aimed at achieving survivor values of cardiac index, DO2, and VO2 fails to improve outcome when instituted following admission to intensive care.