The Body in Pain

Bibliography – Archival Sources

Acknowledgements Introduction Part I. Origin Stories and Political Economy, 1740-1870: 1. History as abstraction 2. Value as signification Part II. Producing the Consumer: 3. Market indicators: banking and housekeeping in Bleak House 4. Esoteric solutions: Ireland and the colonial critique of political economy 5. Toward a social theory of wealth: three novels by Elizabeth Gaskell Conclusion Notes Bibliography Index.

Fiction, Famine, and the Rise of Economics in Victorian Britain and Ireland: History as abstraction

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Fiction, famine, and the rise of economics in Victorian Britain and Ireland

Introduction 1 The 'evangelical': starting out in a Christian culture 2 The apostate: moving beyond the Christian mythos 3 The journalist: editing, reviewing, shaping a worldview 4 The Germanist: balancing the counterweight of German thinkers 5 The novelist: mixing realism, naturalism and myth-making 6 The historian: tracking the idealistic - utopian and national - in Romola and The Spanish Gypsy 7 The 'radical': taking an anti-political stance in Felix Holt 8 The encyclopaedist: transcending the past in Middlemarch 9 The visionary: transmitting ideals in Daniel Deronda 10 The intellectual: cultural critique in Impressions of Theophrastus Such Works cited Index

George Eliot's Intellectual Life

With the passage of the Joint Stock Companies Act of 1856, "a sort of legal monster" was born; composed of many people, and yet legally considered "as one single person," the limited corporations allowed by the Act vexed the notions of subjectivity then current in economic and legal discourse.' In allowing the individual members of corporate bodies to limit their financial responsibility for the debts of those corporations, the Act distinguished sharply between private and public identities-as one contemporary commentator wrote, the investor in a company "and his family" no longer need fear being "stripped of every earthly thing which they possess, even to their very beds. "2 Disengaging and protecting the private elements of subjectivity from the public, the Act paradoxically retained for the corporation as a whole a legal facsimile of the undivided individual. The emergent, limited corporations were thus designed on a model of identity which they themselves, in their very formation, help to antiquate. In debating the limitation of liability, both the members of Parliament and witnesses before the various Select Commissions appointed to consider the issue drew on novelistic vignettes, emblematic stories of individual characters ruined by their investments in failed joint-stock concerns. Speaking of a Blue Book on the issue, Robert Lowe remarked that "a hurried glance at the contents might make a man fancy he was reading a novel."3 The Times, in a diatribe against unlimited joint stock firms, accused these concerns of being fictional creations, composed of "imaginary Higgenses, Wiggenses, and Thompkinses," characters created by "a stroke of the pen." In its own richly imaginative fiction, The Times created a house "taken by the multifarious representative of [a] nascent company in a part of town with which he has the fewest associations." In its physical organization, this house clearly displays the division of public and private within a geographically dispersed economy:

Subjectivity LTD: The Discourse of Liability in the Joint Stock Companies Act of 1856 and Gaskell's Cranford

This paper concerns optative or counterfactual self-understanding both in general and as it shapes the narrative structure, moral psychology, and emotional logic of Charles Dickens's Great Expectations. Who Pip is, in that novel, is thoroughly expressed by his understanding of who he is not; before anything else, he is not the sort of man Estella would love. In claiming that this optative self-understanding structures the narrative he authors, I also propose that it has internal and essential relations to realism more broadly.

"A Case of Metaphysics": Counterfactuals, Realism, Great Expectations

This essay's most narrow aim is to provide a conceptual structure within which to read George Eliot's Impressions of Theophrastus Such. To do this requires I derive what, following Stanley Cavell, I call Eliot's moral perfectionism, for the exacting passions of this perfectionism configure her purposes in Impressions. Eliot's perfectionism is juxtaposed with writing by her contemporaries-Mill, Newman, Bradley, Nietzsche-and by Feuerbach and Spinoza. A further aim of the paper, thus, is to intimate the remarkable reach of this perfectionism in the Victorian period. Finally I conclude by glancing at a consideration of teaching and punishment by Neil Hertz.

Bruising, Laceration, and Lifelong Maiming; Or, How We Encourage Research

Abstract:This essay argues that the shame of stylistic primitivism is central to Edmund Spenser's Shepheardes Calender, which explores the tension between an affiliation with England's linguistic past as a means for shaming the present and as a shameful attachment to a superseded moment in style's evolutionary history. This double perspective on Spenser's conflicted archaism reveals the close bond between style and shame, the social life of style formation and reception, the affectively charged influence of humanism and its stylistic precepts on vernacular literature, and the continued relevance of anachronism as a concept for understanding Renaissance debates over stylistic historicism.

Spenser's Shameful Shepheardes Calender

IGF2BP2 binds to a number of RNA transcripts and has been suggested to function as a tumor promoter, although little is known regarding the mechanisms that regulate its roles in RNA metabolism. Here we demonstrate that IGF2BP2 binds to the 3’ untranslated region of the transcript encoding ATP6V1A, a catalytic subunit of the v‐ATPase, and serves as a novel substrate for the NAD+‐dependent deacetylase SIRT1, which regulates how IGF2BP2 affects the stability of the ATP6V1A transcript. When sufficient levels of SIRT1 are expressed, it catalyzes the deacetylation of IGF2BP2, which can bind to the ATP6V1A transcript but does not mediate its degradation. However, when SIRT1 expression is low, the acetylated form of IGF2BP2 accumulates, and upon binding to the ATP6V1A transcript, recruits the XRN2 nuclease which catalyzes transcript degradation. Thus, the stability of the ATP6V1A transcript is significantly compromised in breast cancer cells when SIRT1 expression is low or knocked‐down. This leads to a reduction in the expression of functional v‐ATPase complexes in cancer cells and to an impairment in their lysosomal activity, resulting in the production of a cellular secretome consisting of increased numbers of exosomes enriched in ubiquitinated protein cargo and soluble hydrolases including cathepsins, that together combine to promote tumor cell survival and invasiveness. These findings describe a previously unrecognized role for IGF2BP2 in mediating the degradation of an mRNA transcript essential for lysosomal function and highlight how its sirtuin‐regulated acetylation state can have significant biological and disease consequences.

Andrew H. Miller

Papers

Subjectivity LTD: The Discourse of Liability in the Joint Stock Companies Act of 1856 and Gaskell's Cranford

"A Case of Metaphysics": Counterfactuals, Realism, Great Expectations

Bruising, Laceration, and Lifelong Maiming; Or, How We Encourage Research

Spenser's Shameful Shepheardes Calender

IGF2BP2 Promotes Cancer Progression by Degrading the RNA Transcript Encoding a v‐ATPase Subunit