R
Richard A. Cerione
Researcher at Cornell University
Publications - 300
Citations - 21292
Richard A. Cerione is an academic researcher from Cornell University. The author has contributed to research in topics: GTPase & GTP'. The author has an hindex of 76, co-authored 281 publications receiving 19400 citations. Previous affiliations of Richard A. Cerione include Ithaca College & University of North Carolina at Chapel Hill.
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Journal ArticleDOI
Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase.
Jintang Du,Yeyun Zhou,Xiaoyang Su,Jiujiu Yu,Saba Khan,Hong Jiang,Jungwoo Kim,Jimin Woo,Jun Huyn Kim,Brian Hyun Choi,Bin He,Wei Chen,Sheng Zhang,Richard A. Cerione,Johan Auwerx,Quan Hao,Quan Hao,Hening Lin +17 more
TL;DR: It is found that Sirt5 is an efficient protein lysine desuccinylase and demalonylase in vitro and may represent a posttranslational modification that can be reversed by Sirt 5 in vivo.
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Insect cell-expressed p180erbb3 possesses an impaired tyrosine kinase activity
TL;DR: It is proposed that p180erbB3 possesses an impaired intrinsic tyrosine kinase activity, which is at least 2 orders of magnitude less efficient than the EGF receptor and capable of binding the ATP analog 5'-p-fluorosulfonylbenzoyladenosine.
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Cdc42 and PAK-mediated Signaling Leads to Jun Kinase and p38 Mitogen-activated Protein Kinase Activation
TL;DR: The PAK family of protein kinases has been suggested as a potential target of the Cdc42 and Rac GTPases based on studies in vitro but it is shown that PAK-3 is activated by CDC42 in vivo and may mediate the effects of cytokines on transcriptional regulation.
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The Dbl family of oncogenes.
Richard A. Cerione,Yi Zheng +1 more
TL;DR: There is still a good deal to learn regarding the biochemical mechanisms that underlie the Dbl family of proteins, and these positive regulators of G proteins to specific cellular locations to carry out the signaling task.
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PAK3 mutation in nonsyndromic X-linked mental retardation
Kristina M. Allen,Joseph G. Gleeson,Joseph G. Gleeson,Shubha Bagrodia,Michael Partington,John MacMillan,Richard A. Cerione,John C. Mulley,Christopher A. Walsh +8 more
TL;DR: Impaired individuals in a multiplex pedigree with MRX (MRX30), previously mapped to Xq22, show a point mutation in the PAK3 (p21-activated kinase) gene, which encodes a serine-threonine kinase, which is critical for human cognitive function.