M
Marc A. Antonyak
Researcher at Cornell University
Publications - 84
Citations - 4483
Marc A. Antonyak is an academic researcher from Cornell University. The author has contributed to research in topics: Microvesicles & Cancer cell. The author has an hindex of 37, co-authored 80 publications receiving 3655 citations. Previous affiliations of Marc A. Antonyak include Thomas Jefferson University.
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Journal ArticleDOI
Cancer cell-derived microvesicles induce transformation by transferring tissue transglutaminase and fibronectin to recipient cells
Marc A. Antonyak,Bo Li,Lindsey K. Boroughs,Jared L. Johnson,Joseph E. Druso,Kirsten L. Bryant,David Holowka,Richard A. Cerione +7 more
TL;DR: It is demonstrated that MV shed by two different human cancer cells are capable of conferring onto normal fibroblasts and epithelial cells the transformed characteristics of cancer cells and that this effect requires the transfer of the protein cross-linking enzyme tissue transglutaminase (tTG).
Journal ArticleDOI
RhoA triggers a specific signaling pathway that generates transforming microvesicles in cancer cells
TL;DR: It is reported that the small GTPase RhoA triggers a specific signaling pathway essential for MV biogenesis in various human cancer cells, and it is demonstrated that blocking MVBiogenesis may offer novel approaches for interfering with malignant transformation.
Journal ArticleDOI
Extracellular vesicle docking at the cellular port: Extracellular vesicle binding and uptake
TL;DR: This work focuses on the mechanisms by which EVs dock and transfer their contents to cells, and highlights how these findings may provide new avenues for therapeutic intervention.
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Constitutive Activation of c-Jun N-terminal Kinase by a Mutant Epidermal Growth Factor Receptor*
TL;DR: Findings implicate constitutive activation of the JNK pathway in transformation by EGFRvIII, a constitutively active, naturally occurring mutation of the EGF receptor that is found in many types of human tumors.
Journal ArticleDOI
A class of extracellular vesicles from breast cancer cells activates VEGF receptors and tumour angiogenesis.
Qiyu Feng,Chengliang Zhang,David H. Lum,Joseph E. Druso,B. Blank,Kristin F. Wilson,Alana L. Welm,Marc A. Antonyak,Richard A. Cerione +8 more
TL;DR: A novel mechanism by which cancer cell-derived MVs influence the tumour microenvironment is revealed and the importance of recognizing their unique properties when considering drug treatment strategies is highlighted.