Andrew J. Fabich

TL;DR: Compared the pathogenic strain and the commensal E. coli strain MG1655 modes of metabolism in vitro, it is found that the two strains used the 13 sugars in a similar order and cometabolized as many as 9 sugars at a time.

TL;DR: There is evidence that aerobic respiration is required for commensal and pathogenic Escherichia coli to colonize mice, and the results indicate that success of the facultative anaerobes in the intestine depends on their respiratory flexibility.

TL;DR: The results show that intestine-adapted E. coli MG1655* is more fit than the wild type for intestinal colonization, because loss of FlhD results in elevated expression of genes involved in carbon and energy metabolism, resulting in more efficient carbon source utilization and a higher intestinal population.

TL;DR: The concept that growth and colonization of E. coli O157:H7 in the bovine rectum has a nutritional basis, with a nutrient preference for l-fucose over N-acetylgalactosamine, is supported.

TL;DR: The model was highly repeatable and novel with respect to streptomycin treatment, use of duodenal cannulas, and repeated colonizations of the same animals, which has implications for understanding intermittency of shedding in the field and for proposed vaccine-based interventions.