Andrew J. Lawrence

TL;DR: The evidence that impulsivity is associated with addiction vulnerability is reviewed by considering three lines of evidence: studies of groups at high-risk for development of SUDs; studies of pathological gamblers, where the harmful consequences of the addiction on brain structure are minimised, and genetic association studies linking impulsivity to genetic risk factors for addiction.

TL;DR: It is indicated that near-misses invigorate gambling through the anomalous recruitment of reward circuitry, despite the objective lack of monetary reinforcement on these trials.

TL;DR: Inhibitory control is impaired in alcohol dependence but occurs in the context of psychomotor slowing, and alcohol-dependent individuals failed to show behavioral adjustment following failed stops, which may represent direct effects of chronic alcohol administration on fronto-striatal circuitry.

TL;DR: The problem gamblers and alcohol-dependent groups displayed impairments in risky decision-making and cognitive impulsivity relative to controls, and shared deficits in tasks linked to ventral prefrontal cortical dysfunction.

TL;DR: Brain network connectivity in SVD is disturbed, this disturbance is related to disease severity, and within a mediation framework fully or partly explains previously observed associations between MRI measures and SVD-related cognitive dysfunction.