A
Andrew J. Samoyedny
Publications - 1
Citations - 1426
Andrew J. Samoyedny is an academic researcher. The author has contributed to research in topics: Insulin receptor & Insulin resistance. The author has an hindex of 1, co-authored 1 publications receiving 1208 citations.
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Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline
Konrad Talbot,Hoau-Yan Wang,Hala Kazi,Li-Ying Han,Kalindi Bakshi,Andres Stucky,Robert L. Fuino,Krista R. Kawaguchi,Andrew J. Samoyedny,Robert S. Wilson,Zoe Arvanitakis,Julie A. Schneider,Bryan A. Wolf,David A. Bennett,John Q. Trojanowski,Steven E. Arnold +15 more
TL;DR: Brain insulin resistance appears to be an early and common feature of AD, a phenomenon accompanied by IGF-1 resistance and closely associated with IRS-1 dysfunction potentially triggered by Aβ oligomers and yet promoting cognitive decline independent of classic AD pathology.