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Andrew K. I. Falconar
Researcher at Universidad del Norte, Colombia
Publications - 52
Citations - 2904
Andrew K. I. Falconar is an academic researcher from Universidad del Norte, Colombia. The author has contributed to research in topics: Dengue virus & Zika virus. The author has an hindex of 25, co-authored 50 publications receiving 2664 citations. Previous affiliations of Andrew K. I. Falconar include University of Oxford & University of London.
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Journal ArticleDOI
Enzyme-Linked Immunosorbent Assay Specific to Dengue Virus Type 1 Nonstructural Protein NS1 Reveals Circulation of the Antigen in the Blood during the Acute Phase of Disease in Patients Experiencing Primary or Secondary Infections
Sophie Alcon,Antoine Talarmin,Monique Debruyne,Andrew K. I. Falconar,Vincent Deubel,Marie Flamand +5 more
TL;DR: Interestingly, NS1 concentrations did not differ significantly in serum specimens obtained from patients experiencing primary or secondary dengue virus infections, indicating that NS1 protein detection may allow early diagnosis of infection.
Journal ArticleDOI
Phylogenetic relationships of flaviviruses correlate with their epidemiology, disease association and biogeography
Michael W. Gaunt,Michael W. Gaunt,Amadou A. Sall,Amadou A. Sall,Xavier de Lamballerie,Andrew K. I. Falconar,Tatyana I. Dzhivanian,Ernest A. Gould +7 more
TL;DR: Phylogenetic analysis of the Flavivirus genus revealed an extensive series of clades defined by their epidemiology and disease associations, which revealed distinct geographical clusters in either the Old World or the New World, which for mosquito-borne viruses may reflect an Old World origin.
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The dengue virus nonstructural-1 protein (NS1) generates antibodies to common epitopes on human blood clotting, integrin/adhesin proteins and binds to human endothelial cells: potential implications in haemorrhagic fever pathogenesis
TL;DR: A potential role of both ‘antigenic’ and ‘biochemical’ mimicry in dengue haemorrhagic fever pathogenesis is identified, consistent with clinical data.
Journal ArticleDOI
Use of recombinant fusion proteins and monoclonal antibodies to define linear and discontinuous antigenic sites on the dengue virus envelope glycoprotein.
Françoise Mégret,J.P. Hugnot,Andrew K. I. Falconar,Mary K. Gentry,David M. Morens,Julie M. Murray,Jacob J. Schlesinger,Peter J. Wright,Paul R. Young,M.H.V. Van Regenmortel,Vincent Deubel +10 more
TL;DR: The results suggest that the maintenance of a topographical arrangement of discontinuous antigenic domains in the flavivirus E-protein is necessary to induce neutralizing and protective antibodies.
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Identification of an epitope on the dengue virus membrane (M) protein defined by cross-protective monoclonal antibodies: design of an improved epitope sequence based on common determinants present in both envelope (E and M) proteins
TL;DR: The protective capacity of monoclonal antibodies generated to the dengue-2 virus envelope and premembrane proteins was tested in vivo and more strongly reacted with an MEH1 peptide GLFTPNLITI, which was designed as an antigenic hybrid between these E and prM peptide sequences.