P
Paul R. Young
Researcher at University of Queensland
Publications - 245
Citations - 10535
Paul R. Young is an academic researcher from University of Queensland. The author has contributed to research in topics: Dengue virus & Virus. The author has an hindex of 49, co-authored 219 publications receiving 8925 citations. Previous affiliations of Paul R. Young include Royal Children's Hospital & Global Virus Network.
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Journal ArticleDOI
High circulating levels of the dengue virus nonstructural protein NS1 early in dengue illness correlate with the development of dengue hemorrhagic fever
Daniel H. Libraty,Paul R. Young,Darren Pickering,Timothy P. Endy,Siripen Kalayanarooj,Sharone Green,David W. Vaughn,Ananda Nisalak,Francis A. Ennis,Alan L. Rothman +9 more
TL;DR: In this paper, the secreted dengue virus nonstructural protein NS1 (sNS1) was measured daily in 32 children with Dengue-2 virus infections participating in a prospective, hospital-based study.
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The Human Immune Response to Dengue Virus Is Dominated by Highly Cross-Reactive Antibodies Endowed with Neutralizing and Enhancing Activity
Martina Beltramello,Katherine L. Williams,Cameron P. Simmons,Annalisa Macagno,Luca Simonelli,Nguyen Than Ha Quyen,Soila Sukupolvi-Petty,Erika Navarro-Sanchez,Paul R. Young,Aravinda M. de Silva,Félix A. Rey,Luca Varani,Stephen S. Whitehead,Michael S. Diamond,Eva Harris,Antonio Lanzavecchia,Federica Sallusto +16 more
TL;DR: These findings reveal an unexpected degree of cross-reactivity in human antibodies against DENV and illustrate the potential for an antibody-based therapy to control severe dengue.
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An Antigen Capture Enzyme-Linked Immunosorbent Assay Reveals High Levels of the Dengue Virus Protein NS1 in the Sera of Infected Patients
TL;DR: The presence of high levels of secreted NS1 in the sera of patients experiencing secondary d Dengue virus infections, and in the context of an anamnestic antibody response, suggests that NS1 may contribute significantly to the formation of the circulating immune complexes that are suspected to play an important role in the pathogenesis of severe dengue disease.
Journal ArticleDOI
The flavivirus NS1 protein: molecular and structural biology, immunology, role in pathogenesis and application as a diagnostic biomarker.
David A. Muller,Paul R. Young +1 more
TL;DR: An overview of these somewhat disparate areas of research is provided, drawing together the wealth of data generated over more than 40 years of study of this fascinating protein, which plays an essential cofactor role in replication.
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Immunolocalization of the Dengue Virus Nonstructural Glycoprotein NS1 Suggests a Role in Viral RNA Replication
TL;DR: Subcellular localization of NS1 and localization of the dsRNA to the vesicle packets and cytoplasmic vacuoles seen in infected Vero and C6/36 cells, respectively, suggests that these structures may comprise the flavivirus replication complex.