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Andrew M. Mikosz
Researcher at Indiana University
Publications - 4
Citations - 455
Andrew M. Mikosz is an academic researcher from Indiana University. The author has contributed to research in topics: Kinocilium & Embryonic stem cell. The author has an hindex of 3, co-authored 3 publications receiving 385 citations.
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Generation of inner ear sensory epithelia from pluripotent stem cells in 3D culture
TL;DR: The stepwise differentiation of inner ear sensory epithelia from mouse embryonic stem cells (ESCs) in three-dimensional culture is reported, establishing a new in vitro model of innerEar differentiation that can be used to gain deeper insight into inner ear development and disorder.
Journal ArticleDOI
Functional development of mechanosensitive hair cells in stem cell-derived organoids parallels native vestibular hair cells
TL;DR: In this article, the potential to generate mechanosensitive hair cells from mouse embryonic stem cells in a three-dimensional (3D) culture system has been investigated, where the system faithfully recapitulates mouse inner ear induction followed by self-guided development into organoids that morphologically resemble inner ear vestibular organs.
Functional development of mechanosensitive hair cells in stem cell-derived organoids parallels native vestibular hair cells
TL;DR: It is concluded that the 3D culture system can generate large numbers of fully functional sensory cells which could be used to investigate mechanisms of inner ear development and disease as well as regenerative mechanisms for inner ear repair.