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Andrew P. Tosolini
Researcher at UCL Institute of Neurology
Publications - 26
Citations - 764
Andrew P. Tosolini is an academic researcher from UCL Institute of Neurology. The author has contributed to research in topics: Axoplasmic transport & Amyotrophic lateral sclerosis. The author has an hindex of 11, co-authored 23 publications receiving 483 citations. Previous affiliations of Andrew P. Tosolini include University of New South Wales & University College London.
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Journal ArticleDOI
Axonal transport and neurological disease.
James N. Sleigh,James N. Sleigh,Alexander M. Rossor,Alexander D. Fellows,Andrew P. Tosolini,Giampietro Schiavo,Giampietro Schiavo +6 more
TL;DR: The latest evidence emerging from human and in vivo studies on whether perturbations in axonal transport are indeed integral to the pathogenesis of neurological disease is reviewed.
Journal ArticleDOI
Spatial characterization of the motor neuron columns supplying the rat forelimb.
Andrew P. Tosolini,Renée Morris +1 more
TL;DR: The anatomical investigation confirmed that motor neurons innervating the rat forelimb are arranged in columns within the cervical segments of the spinal cord, and supports the previous observation that some of the motor neuron columns lying in the cervical aspect of the rat spinal cord are inter-mingled.
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Deacetylation of Miro1 by HDAC6 blocks mitochondrial transport and mediates axon growth inhibition
Ashley L. Kalinski,Ashley L. Kalinski,Amar N. Kar,John Craver,Andrew P. Tosolini,James N. Sleigh,James N. Sleigh,Seung Joon Lee,Alicia L. Hawthorne,Paul Brito-Vargas,Sharmina Miller-Randolph,Ryan Passino,Liang Shi,Victor Wong,Cristina Picci,Deanna S. Smith,Dianna E. Willis,Leif A. Havton,Giampietro Schiavo,Giampietro Schiavo,Roman J. Giger,Brett Langley,Jeffery L. Twiss +22 more
TL;DR: Extracellular stimuli in the injured CNS, such as chondroitin sulfate proteoglycans, inhibit axon growth through activation of the small GTPase RhoA through an converges on an HDAC6-dependent pathway to deacetylate Miro1.
Journal ArticleDOI
The travel diaries of tetanus and botulinum neurotoxins.
Sunaina Surana,Andrew P. Tosolini,Ione Meyer,Alexander D. Fellows,Sergey S. Novoselov,Giampietro Schiavo,Giampietro Schiavo +6 more
TL;DR: TeNT-induced impairment of inhibitory input leads to hyperactivity of motor neurons, causing spastic paralysis, which is the hallmark of tetanus, and the molecular mechanisms leading to the entry, sorting and intracellular trafficking are examined.
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Impaired arpeggio movement in skilled reaching by rubrospinal tract lesions in the rat: a behavioral/anatomical fractionation.
TL;DR: The results show that not only does the LF contribute to skilled reaching, but because the R ST was likely to have been damaged in all lesion groups, the RST is more involved in hand rotation than in digit use.