Andrew S. Peek

TL;DR: An integrated set of bioinformatics tools that predict the properties of native and chemically modified nucleic acids and assist in their design and find the most suitable sequences for RNA interference, calculate stable secondary structures, and evaluate the potential for two sequences to interact are created.

TL;DR: Testing the hypothesis that increased formation of superoxide (O2-*) radicals from a Rac1-regulated Nox2-containing NADPH oxidase is a key upstream mediator of ANG II-induced activation of serine-threonine kinase Akt suggests that dysregulation of this signaling cascade may play an important role in cardiac hypertrophy.

TL;DR: A novel approach that combines cell-internalization SELEX with high-throughput sequencing and bioinformatics analysis to rapidly identify cell-specific, internalization-competent RNA aptamers is described, which is expected to enable the identification of aptamer to a multitude of different cell types, thereby facilitating the broad development of targeted cell therapies.

TL;DR: Small interfering RNAs have become the experimental tool of choice to suppress gene expression in a wide variety of organisms and chemical modification of the RNA can improve function by improving stability, reducing the potential for off-target effects and avoiding stimulation of the innate immune system.

TL;DR: This microarray will enable researchers to generate a global view of gene expression in C. reinhardtii and may be of interest for laboratories interested in developing microarrays for organisms whose genome sequences are not yet completed (but are nearing completion).