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Andrew S. Rakeman
Researcher at Cornell University
Publications - 5
Citations - 1773
Andrew S. Rakeman is an academic researcher from Cornell University. The author has contributed to research in topics: Notochord & Sonic hedgehog. The author has an hindex of 4, co-authored 5 publications receiving 1646 citations. Previous affiliations of Andrew S. Rakeman include Kettering University.
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Journal ArticleDOI
Hedgehog signalling in the mouse requires intraflagellar transport proteins
Danwei Huangfu,Aimin Liu,Aimin Liu,Andrew S. Rakeman,Andrew S. Rakeman,Noel S. Murcia,Lee Niswander,Lee Niswander,Kathryn V. Anderson +8 more
TL;DR: Genetic analysis shows that Wim, Polaris and the IFT motor protein Kif3a are required for Hedgehog signalling at a step downstream of Patched1 (the Hedgehog receptor) and upstream of direct targets of hedgehog signalling.
Journal ArticleDOI
Mouse Dispatched homolog1 Is Required for Long-Range, but Not Juxtacrine, Hh Signaling
Tamara Caspary,María J. García-García,Danwei Huangfu,Danwei Huangfu,Jonathan T. Eggenschwiler,Michael R. Wyler,Andrew S. Rakeman,Andrew S. Rakeman,Heather L. Alcorn,Kathryn V. Anderson +9 more
TL;DR: This work has identified recessive ENU-induced mutations in six genes that prevent normal specification of ventral cell types in the spinal cord, and positionally cloned the genes responsible for two of the mutant phenotypes, smoothened and dispatched, which are homologs of Drosophila Hh pathway components.
Journal ArticleDOI
Analysis of mouse embryonic patterning and morphogenesis by forward genetics
María J. García-García,Jonathan T. Eggenschwiler,Tamara Caspary,Heather L. Alcorn,Michael R. Wyler,Danwei Huangfu,Andrew S. Rakeman,Jeffrey D. Lee,Evan H. Feinberg,John R. Timmer,Kathryn V. Anderson +10 more
TL;DR: In this paper, a forward genetic approach was used to induce recessive mutations by treatment of mice with ethylnitrosourea and identified 43 mutations that affect early morphogenesis and patterning, including 38 genes that have not been studied previously.
Journal ArticleDOI
Axis specification and morphogenesis in the mouse embryo require Nap1, a regulator of WAVE-mediated actin branching.
TL;DR: In this article, it was shown that mouse embryos that lack Nap1, a regulatory component of the WAVE complex, arrest at midgestation and have defects in morphogenesis of all three embryonic germ layers.