Showing papers in "Developmental Biology in 2008"

TL;DR: Recent data that are suggestive of specific ROS functions during development of animals, particularly mammals are reviewed.

TL;DR: Data place Wnt/beta-catenin signaling upstream of key morphogenetic signaling pathways at multiple stages of tooth development and indicate that tight regulation of this pathway is essential both for patterning tooth development in the dental lamina, and for controlling the shape of individual teeth.

TL;DR: It is shown that C dx2 is initially ubiquitously expressed, and becomes progressively upregulated in outside, future trophectoderm cells prior to blastocyst formation, suggesting that processes influencing lineage allocation or morphogenesis may regulate Cdx2 expression along the inside/outside axis of the embryo.

TL;DR: Data indicate that cells present at prospective joint sites and expressing Gdf5 constitute a distinct cohort of progenitor cells responsible for limb joint formation, which appear to be patterned along specific limb symmetry axes and rely on local signaling tools to make distinct contributions to joint formation.

TL;DR: Results show that inhibition of Nodal signaling promotes neuronal specification, indicating a role for this pathway in controlling early neural development of pluripotent cells.

TL;DR: A principal physiologic role of the PI3K pathway is to control primordial follicle activation through the forkhead transcription factor Foxo3 within oocytes and throughout life.

TL;DR: A number of cellular behaviours, such as cell divisions, cell rearrangements and dynamic alterations in cell-cell contacts, have to be considered when studying the morphological and molecular processes involved in ISV and endothelial lumen formation in vivo.

TL;DR: Molecular fate mapping is used to demonstrate that the majority of cell types within the metanephric kidney arise from an Osr1(+) population of metAnephric progenitor cells, and lend support to a model where Osr 1 function is limited to establishing the nephron progenitors pool.

TL;DR: This work shows that Kif3a is essential for Shh-dependent expansion of cerebellar progenitors and Dysfunctional cilia are associated with diverse human disorders including Bardet-Biedl and Joubert syndromes.

TL;DR: By exploiting the temporally regulated Cre recombinase, these studies show that nephronic epithelium arising at different stages of nephrogenesis has distinct spatial distribution in the adult kidney, and demonstrate for the first time that the cap mesenchyme includes a population of self-renewing epithelial progenitor cells.

TL;DR: Differential requirements of distinct MRFs for the induction of microRNA gene expression during skeletal myogenesis are demonstrated, demonstrating a regulation by muscle regulatory factors.

TL;DR: It is shown that the germ line is required for the ovary versus testis fate choice in zebrafish and that testis specification is sufficient for masculinization of the fish pointing to a direct role of hormone signaling from the gonad in directing sex differentiation of non-gonadal tissues.

TL;DR: Analysis of transcripts indicated that the strength of the spindle assembly checkpoint is weakened and that higher errors of microtubule-kinetochore interactions constitute part of molecular basis for the age-associated increase in aneuploidy in females.

TL;DR: Transgenic mice are developed that express a doxycycline inducible Sox2 in the airway epithelium that prevents airways from branching and prematurely drives cells into committed progenitors, apparently rendering these committed progensitors unresponsive to branch inducing signals.

TL;DR: The anterior location of the mesoderm-derived hypochiasmatic cartilages, which are closely linked with the extra-ocular muscles, suggests that some tissues associated with the visual apparatus may have evolved independently of the rest of the "New Head".

TL;DR: It is suggested that, like the spinal cord, neuronal fate determination in the ventral telencephalon is largely the result of spatially segregated, molecularly distinct microdomains arranged on the dorsal-ventral axis.

TL;DR: The expanded Isl1 and Nkx2-5 cardiac fate maps were remarkably similar, and included extensive contributions to cardiomyocyte, endocardial, and smooth muscle lineages in all four cardiac chambers.

TL;DR: It is demonstrated that bucky ball functions during early oogenesis to regulate polarity of the oocyte, future egg and embryo, and the expansion of animal identity in oocytes and somatic follicle cells suggests that somatic cell fate and oocyte polarity are interdependent.

TL;DR: This mutant, the first knockout of a vertebrate TMEM16 family member, provides a mouse model of tracheomalacia and identifies Tmem16a as a novel regulator of epithelial and smooth muscle cell organization in murine development.

TL;DR: In this article, a review covers recent studies that have analyzed how these Ca(2+) signals are interpreted by specific proteins, and how these proteins regulate various EEA responsible for the onset of development.

TL;DR: The data support a model whereby GATA4 or GATA6 are essential for expression of the network of transcription factors that regulate the onset of cardiac myocyte gene expression during mammalian development.

TL;DR: This system and its behavior constitute an extraordinarily rich set of materials for the study of canalization and embryonic regulation at the molecular level, and is the first quantitatively characterized morphogenetic field.

TL;DR: It is indicated that Pdx-1 and Ptf1a have distinct but interdependent functions during pancreatic MPC specification and differentiation, which is in contrast to the deletion of PTF1a.

TL;DR: This work characterized activity, stability, and gradient formation of a truncated form of Dpp (Dpp(Delta N), which lacks a short domain at the N-terminus essential for its interaction with Dally and proposes a model in which Dally regulates Dpp distribution and signaling by disrupting receptor-mediated internalization and degradation of the Dpp-receptor complex.

TL;DR: An important and time-dependent role for wnt signaling during liver development and regeneration is revealed and the conserved effect of Wnt pathway activation in liver regeneration across vertebrate species is indicated.

TL;DR: Using chondrogenic and osteogenic markers it is shown that redifferentiation does not occur by endochondral ossification but by the direct ossify of blastema cells that form the rudiment of the digit tip that is consistently shorter than unamputated control digits.

TL;DR: An enhancer trap transgenic zebrafish line, ETvmat2:GFP, in which most monoaminergic neurons are labeled by green fluorescent protein (GFP) during embryonic development is described, and it is shown that the effects of hedgehog signaling pathway inhibition on the development of monoaminationergic neurons can be easily visualized in individual living ETvMat2: GFP embryos.

TL;DR: It is proposed that pdx1 is required for proliferation and function of the beta cells generated at late gestation, and that one function of normal beta cells is to inhibit the proliferation of other islet cell types, resulting in the appropriate numbers of the different endocrine cell types.

TL;DR: It is demonstrated by whole-mount immunofluorescence staining of ear skin and mesentery that lymphatic vessels in Ang2(-/-) mice fail to mature and do not exhibit a collecting vessel phenotype, and the sequential steps in lymphatic vessel remodeling are defined.

TL;DR: It is demonstrated that Fgfr2 functions in the proliferating and invading TEBs, but it is not required in the mature ducts of the pubertal mammary gland.