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Andrew Skorobogaty
Researcher at La Trobe University
Publications - 14
Citations - 506
Andrew Skorobogaty is an academic researcher from La Trobe University. The author has contributed to research in topics: DNA & Molecular recognition. The author has an hindex of 8, co-authored 13 publications receiving 499 citations. Previous affiliations of Andrew Skorobogaty include Monash University, Clayton campus.
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Molecular recognition between oligopeptides and nucleic acids: novel imidazole-containing oligopeptides related to netropsin that exhibit altered DNA sequence specificity.
TL;DR: Oligopeptides have been synthesized that are structurally related to the antiviral antitumor antibiotic netropsin, but in which each of the pyrrole units is successively replaced by an imidazole moiety, as well as their di- and triimidazoles-containing counterparts.
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DNA cleavage specificity of a group of cationic metalloporphyrins.
TL;DR: Analysis of the mechanism of porphyrin-mediated strand breakage in terms of the DNA cleavage mechanism of methidium-propyl-iron-EDTA and Fe-bleomycin, the potential of the cationic metalloporphyrins as footprinting probes and as new "reporter ligands" for DNA is presented and discussed.
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Electron spin resonance spectroscopic and spectrophotometric investigation of the binding of tetracationic porphyrins and porphyrazines with calf thymus DNA. Unequivocal evidence for intercalation
TL;DR: In this article, the authors show that the planar tetracationic metallo-macrocyclic dye can intercalate with calf thymus DNA in aqueous electrolyte solution.
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Deoxyribonucleic acid cleavage specificity of a series of acridine- and acodazole-iron porphyrins as functional bleomycin models.
TL;DR: Comparison of the Kassoc values for binding to calf thymus DNA suggests that the enhanced binding observed with the linker -NH(CH2)3 NH(CH 2)3- contributes to the efficiency of sequence neutral DNA scission and may be a factor in the relative anticancer activities of these agents.
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The 5'-CA DNA-sequence preference of daunomycin.
TL;DR: The preference of daunomycin for 5′‐CA nucleotide sequence suggests that its biological activity may arise from association with the 5‐CA‐containing sequences thought to be associated with genetic regulatory elements in eukaryotes.