Andrew W. E. Wright

TL;DR: In this paper, the authors quantify the neuro-excitatory behaviours evoked by intracerebroventricular (icv) H3G in the rat and define its potency relative to M3G.

TL;DR: An original, sensitive, and specific high-performance liquid chromatographic (HPLC) assay was developed for the quantitation of morphine and its two major metabolites, morphine-3-glucuronide (M3G) and morphine-6- glucuronides (M6G), in human plasma and cerebrospinal fluid (CSF) and in rat plasma, using hydromorphone as the internal standard.

TL;DR: The serum protein binding of both oxycodone and morphine was independent of drug concentration in the therapeutic range (5–100 ng/ml), but was dependent on protein concentration, which increased with increasing concentrations of both albumin and A AG.

TL;DR: A preliminary evaluation of H3G's intrinsic pharmacological effects revealed that following i.c.v. administration to adult male Sprague-Dawley rats in a dose of 5 microg, H2G evoked a range of excitatory behavioural effects including chewing, rearing, myoclonus, ataxia and tonic-clonic convulsions, in a manner similar to that reported previously for the glucuronide metabolites of morphine.

TL;DR: Female and castrated male rats developed tolerance more slowly than either intact male or testosterone-pretreated female rats, when coinfused with parenteral morphine plus chloramphenicol, implying that testosterone modulates antinociception evoked by prolonged morphine infusion in rats via a mechanism that appears to involve modulation of morphine metabolism.