Showing papers in "Life Sciences in 2001"

TL;DR: The combination of relatively high affinity for amyloid, specificity for staining plaques and neurofibrillary tangles in post-mortem AD brain, and good brain entry and clearance makes [N-methyl-11C]6-Me-BTA-1 a promising candidate as an in vivo positron emission tomography (PET) beta-sheet imaging agent.

TL;DR: It is suggested that inhibition of iNOS and COX-2 expression by flavonoids may be one of the mechanisms responsible for their anti-inflammatory effects.

TL;DR: Two mechanisms can be proposed for neuroprotection by late NMDA receptor blockade, i.e., blocking of presynaptic release of glutamate after excessive activation of glutamate receptors, and blocking of postsynaptic sensitization of NMDA receptors.

TL;DR: A comprehensive study of the diurnal free cortisol cycle designed to analyse its components and to investigate their reliability and inter-relatedness is reported.

TL;DR: It is reported here that after incubation with holotransferrin, which increases the concentration of ferrous iron in cancer cells, dihydroartemisinin, an analog of artemis inin, effectively killed a type of radiation-resistant human breast cancer cell in vitro.

TL;DR: The results suggest that EGCG has protective effects against βA-induced neuronal apoptosis through scavenging reactive oxygen species, which may be beneficial for the prevention of Alzheimer's disease.

TL;DR: It is suggested that chronic exercise causes an increase in production of NO and a decrease inProduction of ET-1 in humans, which may produce beneficial effects (i.e., vasodilative and antiatherosclerotic) on the cardiovascular system.

TL;DR: Results provide the first evidence for the involvement of the vanilloid receptor in the acid-induced inflammatory pain perception via sensory C-fibers in addition to the known mediators bradykinin, neurokinins, and prostanoids.

TL;DR: It is shown that intracerebroventricular STZ may be appropriate model for investigations of antioxidants as potential treatment in Alzheimer's dementia and a development of oxidative stress in the brain is demonstrated.

TL;DR: The various molecular steps of apoptosis are summarized and there is evidence to suggest that, under certain conditions and in some cell types; these two pathways may cross talk.

TL;DR: The data show that daytime fasting, modifications in sleep schedule and psychological and social habits during Ramadan induce changes in the rhythmic pattern of a number of hormonal variables.

TL;DR: Results would appear to indicate that naringin, a citrus bioflavonoid, plays an important role in regulating antioxidative capacities by increasing the SOD and catalase activities, up-regulating the gene expressions of SOD,Catalase, and GSH-Px, and protecting the plasma vitamin E.

TL;DR: Treatment with two HPBCDs had effects in delaying neurological symptoms and in decreasing liver cholesterol storage while a third HPBCD was without effect and the ameliorating effect was not improved by longer exposure times (commencement of exposure in utero), however, it is not known if there is transplacental transfer of HPBCDS.

TL;DR: Green tea catechins, except EC which was inactive, and other 3 GTCs were found to suppress the growth and induce apoptosis in human prostate cancer DU145 cells largely through an increase in reactive oxygen species formation and mitochondrial depolarization.

TL;DR: The results of the study indicate that resveratrol modulates several human immune cell functions and suggest that this activity may be related to its effects on cytokine production by both CD4+ and CD8+ T cells.

TL;DR: The study suggests resveratrol is a potent neuroprotective agent in focal cerebral ischemia and its beneficial effects may be related to its anti-platelet aggregation activity, vasodilating effect, antioxidant property or by all mechanisms together.

TL;DR: It is concluded that doxorubicin induces cardiotoxicity through lipid peroxidation and melatonin is an effective antioxidant against the reactive oxygen intermediates generated by DOX.

TL;DR: The present findings suggest that hydroxy fasudil has an efficacy to improve the hemodynamic function and to inhibit neutrophil-mediated damage, and contributes to the potency and long duration of the cytoprotective properties of f asudil on ischemic brain damage; and also suggest a critical role for rho kinase in the pathogenesis of cerebral isChemic injury, and the potential utility of rho Kinase inhibitor as a therapeutic agent in stroke.

TL;DR: It is demonstrated that crocin suppresses the effect of tumor necrosis factor (TNF)-alpha on neuronally differentiated PC-12 cells and inhibits neuronal cell death induced by both internal and external apoptotic stimuli.

TL;DR: The phenolics found in virgin olive oil possess ability to scavenge reactive oxygen and nitrogen species that are implicated in human pathologies, but their impact may be restricted to those species present in the extracellular environment.

TL;DR: The results suggest that urethane is preferable to K/X for anesthetized cystometry studies since it more closely simulates normal physiological responses.

TL;DR: The findings suggest that impaired homeostasis of oxygen/nitrogen radicals and increased oxidative stress are involved in the pathophysiology of childhood AD, and indicate that suppression of oxidative stress might be a potentially useful strategy for the treatment of AD.

TL;DR: In this article, the protein levels of complex I 24 and 75-kDa subunits in several brain regions from patients with Down syndrome (DS) and Alzheimer's disease (AD) were studied.

TL;DR: The present experiments were performed to define the time-course, isozyme subtypes, and cellular source of increased MMP expression that occurs following MI in an experimental rabbit model and speculate that the net increase in proteolytic activity by myocytes is a contributing factor leading to myocyte misalignment and slippage.

TL;DR: The findings suggest that the amounts of D2 receptor declines in all brain regions as part of the normal aging process.

TL;DR: It is confirmed that prodigiosin induces apoptosis in both cancer cell lines by the characteristic DNA laddering pattern and condensed nuclei or apoptotic bodies identified by fluorescence microscopy.

TL;DR: These results demonstrate that Hcy exerted its genotoxic effects on HL-60 cells through an apoptotic pathway, which is mediated by the activation of caspase 3 activity induced by an increase in intracellular hydrogen peroxide.

TL;DR: The mixed commercial antioxidant, which suppressed lipid peroxidation and protected membrane proteins against degradation induced by peroxyl radicals, also effectively delayed AAPH induced haemolysis, which provides a sound objective basis for the in vitro comparison of the potential efficacy of the hundreds of antioxidant nutritional supplements currently available in the market place.

TL;DR: Electrical stimulation near Ch6 induced dopamine release in the nucleus accumbens in two phases, an early phase dependent on nicotinic and gluatamatergic receptors in VTA, and aLate phase was lost in M5 mutant mice, while the early phase was unchanged.

TL;DR: In this paper, an antiserum was raised in a rabbit against a synthetic peptide corresponding to amino acid residues 248-260 of the third intracellular loop of the rat GHS-R.