Andrew Yueh

TL;DR: It is demonstrated that the 5' noncoding region of human adenovirus late mRNAs utilizes a striking complementarity to 18S rRNA to facilitate a novel form of translation initiation referred to as ribosome shunting, in which 40S ribosomes bind the cap and bypass large segments of the mRNA to reach the initiation codon.

TL;DR: This report shows that the family of adenovirus late mRNAs, which are preferentially translated during infection, use a ribosome jumping mechanism to initiate protein synthesis, and proposes that shunting may represent a widespread mechanism to facilitate selective translation of specialized classes of capped m RNAs, including some stress and developmentally regulated mRNas, which possess little requirement for eIF-4F but do not initiate by internal ribosomes.

TL;DR: In vitro antiviral experiments showed that baicalin as the main metabolite of baicalein exerting in vitro anti-DENV activity, and showed anti-adsorption effect with IC50 = 18.07 ± 0.2 μg/ml.

TL;DR: A successful example of employing structure-based virtual screening, a method that combines shape-based database search with a docking study and analogue search, to discover a novel family of PPARgamma agonists based upon pyrazol-5-ylbenzenesulfonamide.

TL;DR: This novel strategy of constructing DENV2 and JEV infectious clones could be applied to other flaviviruses or pathogenic RNA viruses to facilitate research in virology, viral pathogenesis, and vaccine development.