N
Neeraj Mahindroo
Researcher at University of Petroleum and Energy Studies
Publications - 46
Citations - 1483
Neeraj Mahindroo is an academic researcher from University of Petroleum and Energy Studies. The author has contributed to research in topics: Medicine & Hedgehog signaling pathway. The author has an hindex of 19, co-authored 42 publications receiving 1286 citations. Previous affiliations of Neeraj Mahindroo include Council of Scientific and Industrial Research & Panjab University, Chandigarh.
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Journal ArticleDOI
Pharmaceutical design of antimitotic agents based on combretastatins.
TL;DR: This review will particularly elucidate the rationale and strategic tactics towards the development of novel classes of antimitotic agents, based upon combretastatin A-4 as a promising lead.
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Hedgehog-Gli Signaling Pathway Inhibitors as Anticancer Agents
TL;DR: The medicinal chemistry efforts to identify and design inhibitors of Hh-Gli signaling are reviewed and a perspective of future developments in this dynamic field is presented.
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Structure-Based Drug Design and Structural Biology Study of Novel Nonpeptide Inhibitors of Severe Acute Respiratory Syndrome Coronavirus Main Protease
I-Lin Lu,Neeraj Mahindroo,Po-Huang Liang,Yi-Hui Peng,Chih-Jung Kuo,Keng-Chang Tsai,Hsing Pang Hsieh,Yu-Sheng Chao,Su-Ying Wu +8 more
TL;DR: Interestingly, the most potent inhibitor induces protein conformational changes, and the inhibition mechanisms, particularly the disruption of catalytic dyad (His41 and Cys145), are elaborated.
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Structure-based drug design of a novel family of PPARgamma partial agonists: virtual screening, X-ray crystallography, and in vitro/in vivo biological activities.
I-Lin Lu,Chien-Fu Huang,Yi-Hui Peng,Ying-Ting Lin,Hsing Pang Hsieh,Chiung-Tong Chen,Tzu-Wen Lien,Hwei Jen Lee,Neeraj Mahindroo,Ekambaranellore Prakash,Andrew Yueh,Hsin-Yi Chen,Chandra M. V. Goparaju,Xin Chen,Chun-Chen Liao,Yu-Sheng Chao,John T.A. Hsu,Su-Ying Wu +17 more
TL;DR: A successful example of employing structure-based virtual screening, a method that combines shape-based database search with a docking study and analogue search, to discover a novel family of PPARgamma agonists based upon pyrazol-5-ylbenzenesulfonamide.
Journal ArticleDOI
Novel indole-based peroxisome proliferator-activated receptor agonists: design, SAR, structural biology, and biological activities.
Neeraj Mahindroo,Chien-Fu Huang,Yi-Huei Peng,Chiung-Chiu Wang,Chun-Chen Liao,Tzu-Wen Lien,Santhosh Kumar Chittimalla,Wei-Jan Huang,Chia-Hua Chai,Ekambaranellore Prakash,Ching-Ping Chen,Tsu-An Hsu,Cheng-Hung Peng,I-Lin Lu,Ling-Hui Lee,Yi-Wei Chang,Wei Cheng Chen,Yu-Chen Chou,Chiung-Tong Chen,Chandra M. V. Goparaju,Yuan-Shou Chen,Shih-Jung Lan,Ming-Chen Yu,Xin Chen,Yu-Sheng Chao,Su-Ying Wu,Hsing Pang Hsieh +26 more
TL;DR: In vitro evaluation led to identification of a novel series of indole compounds with a benzisoxazole tail as potent PPAR agonists with the lead compound 14 displaying an excellent pharmacokinetic profile in BALB/c mice and an efficacious glucose lowering activity in KKA(y) mice.