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The boundary layer equations for plane, incompressible, and steady flow are 

$$\matrix{ {u{{\partial u} \over {\partial x}} + v{{\partial u} \over {\partial y}} = - {1 \over \varrho }{{\partial p} \over {\partial x}} + v{{{\partial ^2}u} \over {\partial {y^2}}},} \cr {0 = {{\partial p} \over {\partial y}},} \cr {{{\partial u} \over {\partial x}} + {{\partial v} \over {\partial y}} = 0.} \cr }$$

Boundary Layer Theory

Boundary-layer flow of a nanofluid past a stretching sheet

The flow of homogeneous fluids through porous media: analogies with other physical problems

Natural convective boundary-layer flow of a nanofluid past a vertical plate

Effect of pharmaceutical agent degradation on axonal transport drug delivery: An analytical solution for a transient situation ☆

Effect of the width of regions with severed microtubules on transport of organelles down the axon

In neurons, neuropeptides are synthesized in the soma and are then transported along the axon in dense-core vesicles (DCVs). DCVs are captured in varicosities located along the axon terminal called en passant boutons, which are active terminal sites that accumulate and release neurotransmitters. Recently developed experimental techniques allow for the estimation of the age of DCVs in various locations in the axon terminal. Accurate simulation of the mean age of DCVs in boutons requires the development of a model that would account for resident, transiting-anterograde and transiting-retrograde DCV populations. In this paper, such a model is developed. The model is applied to simulating DCV transport in Drosophila type II motoneurons. The model simulates DCV transport and capture in the axon terminals and makes it possible to predict the age density distribution of DCVs in en passant boutons as well as DCV mean age in boutons. The predicted prevalence of older organelles in distal boutons may explain the 'dying back' pattern of axonal degeneration observed in dopaminergic neurons in Parkinson's disease. The predicted difference of two hours between the age of older DCVs residing in distal boutons and the age of younger DCVs residing in proximal boutons is consistent with an approximate estimate of age difference deduced from experimental observations. The age density of resident DCVs is found to be bimodal, which is because DCVs are captured from two transiting states: the anterograde transiting state that contains younger DCVs and the retrograde transiting state that contains older DCVs.

https://royalsocietypublishing.org/doi/pdf/10.1098/rspa.2020.0454

How old are dense-core vesicles residing in en passant boutons: simulation of the mean age of dense-core vesicles in axonal arbours accounting for resident and transiting vesicle populations

The linear stability of the parallel Darcy throughflow in a horizontal plane porous layer with impermeable boundaries subject to a symmetric net heating or cooling is investigated. The onset conditions for the secondary thermoconvective flow are expressed through a neutral stability bound for the Darcy–Rayleigh number associated with the uniform heat flux supplied or removed from the walls. The study is performed by taking into account a condition of local thermal nonequilibrium between the solid phase and the fluid phase. The linear stability analysis is carried out according to the normal modes' decomposition of the perturbations to the basic state. The governing equations for the disturbances are solved numerically as an eigenvalue problem leading to the neutral stability condition. If compared with the asymptotic condition of local thermal equilibrium, the regime of local nonequilibrium manifests an enhanced instability. This behavior is displayed by lower critical values of the Darcy–Rayleigh number, eventually tending to zero when the thermal conductivity of the solid phase is much larger than the conductivity of the fluid phase. In this special limit, which can be invoked as an approximate model of a gas-saturated metallic foam, the basic throughflow is always unstable to external disturbances of arbitrarily small amplitude.

Convective Instability of the Darcy Flow in a Horizontal Layer With Symmetric Wall Heat Fluxes and Local Thermal Nonequilibrium

In this paper a model of targeted drug delivery by means of active (motor-driven) axonal transport is developed. The model is motivated by recent experimental research by Filler et al. (A.G. Filler, G.T. Whiteside, M. Bacon, M. Frederickson, F.A. Howe, M.D. Rabinowitz, A.J. Sokoloff, T.W. Deacon, C. Abell, R. Munglani, J.R. Griffiths, B.A. Bell, A.M.L. Lever, Tri-partite complex for axonal transport drug delivery achieves pharmacological effect, Bmc Neuroscience 11 (2010) 8) that reported synthesis and pharmacological efficiency tests of a tri-partite complex designed for axonal transport drug delivery. The developed model accounts for two populations of pharmaceutical agent complexes (PACs): PACs that are transported retrogradely by dynein motors and PACs that are accumulated in the axon at the Nodes of Ranvier. The transitions between these two populations of PACs are described by first-order reactions. An analytical solution of the coupled system of transient equations describing conservations of these two populations of PACs is obtained by using Laplace transform. Numerical results for various combinations of parameter values are presented and their physical significance is discussed.

Andrey V. Kuznetsov

Papers

Effect of pharmaceutical agent degradation on axonal transport drug delivery: An analytical solution for a transient situation ☆

Effect of the width of regions with severed microtubules on transport of organelles down the axon

How old are dense-core vesicles residing in en passant boutons: simulation of the mean age of dense-core vesicles in axonal arbours accounting for resident and transiting vesicle populations

Convective Instability of the Darcy Flow in a Horizontal Layer With Symmetric Wall Heat Fluxes and Local Thermal Nonequilibrium

A model of axonal transport drug delivery