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Andriy Buchynskyy
Researcher at University of Washington
Publications - 4
Citations - 304
Andriy Buchynskyy is an academic researcher from University of Washington. The author has contributed to research in topics: Trypanosoma brucei & Classical pharmacology. The author has an hindex of 3, co-authored 4 publications receiving 251 citations.
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Recent developments in drug discovery for leishmaniasis and human African trypanosomiasis.
Advait Nagle,Shilpi Khare,Arun Kumar,Frantisek Supek,Andriy Buchynskyy,Casey J. N. Mathison,Naveen Kumar Chennamaneni,Nagendar Pendem,Frederick S. Buckner,Michael H. Gelb,Valentina Molteni +10 more
TL;DR: The disease history and parasite biology is described followed by a summary of the currently available treatments and, finally, review reports of novel small molecules with antileishmanial activity.
Journal ArticleDOI
1-Benzyl-3-aryl-2-thiohydantoin Derivatives as New Anti-Trypanosoma brucei Agents: SAR and in Vivo Efficacy
Andriy Buchynskyy,J. Robert Gillespie,Zackary M. Herbst,Renae M. Ranade,Frederick S. Buckner,Michael H. Gelb +5 more
TL;DR: In vivo efficacy experiments in an acute mouse model of Human African Trypanosomiasis showed a 100% cure rate after 4 days of oral treatment at 50 mg/kg twice per day, which represents >100-fold improvement in potency compared to compound 1.
Journal ArticleDOI
Discovery of N-(2-aminoethyl)-N-benzyloxyphenyl benzamides: New potent Trypanosoma brucei inhibitors.
Andriy Buchynskyy,J. Robert Gillespie,Matthew A. Hulverson,Joshua McQueen,Sharon A. Creason,Ranae M. Ranade,Nicole A. Duster,Michael H. Gelb,Frederick S. Buckner +8 more
TL;DR: Compound 73 was orally bioavailable and displayed good plasma and brain exposure in mice, cured 2 out of 3 mice infected with Trypanosoma brucei in acute model when dosed orally at 50mg/kg once per day for 4days.
Journal ArticleDOI
Phenotypic Drug Discovery for Human African Trypanosomiasis: A Powerful Approach.
Frederick S. Buckner,Andriy Buchynskyy,Pendem Nagendar,Donald A. Patrick,J. Robert Gillespie,Zackary M. Herbst,Richard R. Tidwell,Michael H. Gelb +7 more
TL;DR: This research demonstrates the power of the phenotypic drug discovery approach for neglected tropical diseases by screening a library of 700,000 small molecules for inhibitors of Trypanosoma brucei growth without knowledge of the mechanism of action for the compounds.