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Anett Doerfelt
Researcher at University of Regensburg
Publications - 7
Citations - 413
Anett Doerfelt is an academic researcher from University of Regensburg. The author has contributed to research in topics: Glioma & Small interfering RNA. The author has an hindex of 6, co-authored 7 publications receiving 371 citations.
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Journal ArticleDOI
Lactate promotes glioma migration by TGF-beta2-dependent regulation of matrix metalloproteinase-2.
Fusun Baumann,Petra Leukel,Anett Doerfelt,Christoph P. Beier,Katja Dettmer,Peter J. Oefner,Michael Kastenberger,Marina Kreutz,Thomas Nickl-Jockschat,Ulrich Bogdahn,Anja-Katrin Bosserhoff,Peter Hau +11 more
TL;DR: It is demonstrated that TGF-beta2 enhances expression, secretion, and activation of matrix metalloproteinase-2 (MMP-2) and induces the cell surface expression of integrin alpha(v)beta(3) receptors, which might constitute a crucial mechanism for glioma migration.
Journal ArticleDOI
The role of versican isoforms V0/V1 in glioma migration mediated by transforming growth factor-beta2
F. Arslan,Anja-Kathrin Bosserhoff,Thomas Nickl-Jockschat,Anett Doerfelt,Ulrich Bogdahn,Peter Hau +5 more
TL;DR: It is reported here that TGF-β2 triggers the malignant phenotype of high-grade gliomas by induction of migration, and that this effect is, at least in part, mediated by versican V0/V1.
Journal ArticleDOI
An imbalance between Smad and MAPK pathways is responsible for TGF-beta tumor promoting effects in high-grade gliomas.
Thomas Nickl-Jockschat,F. Arslan,Anett Doerfelt,Ulrich Bogdahn,Anja-Kathrin Bosserhoff,Peter Hau +5 more
TL;DR: The results suggest that combined antagonization of the TGF-beta and MAPK pathways might be a promising approach for glioma therapy and indicate the involvement of K-ras in T GF-beta signaling in high-grade gliomas.
Journal Article
Implementation of a cost-effective HPLC/UV-approach for medical routine quantification of donepezil in human serum
Ralf Koeber,Hans-Hermann Kluenemann,Reinhold Waimer,Anton Koestlbacher,Markus Wittmann,Regina Brandl,Anett Doerfelt,Tatjana Jahner,D Melchner,Ekkehard Haen +9 more
TL;DR: In this article, a simple, specific and sensitive high performance liquid chromatography (HPLC) assay for the detection and quantification of donepezil in serum of demented patients has been developed and validated.
Journal ArticleDOI
Implementation of a cost-effective HPLC/UV-approach for medical routine quantification of donepezil in human serum.
Ralf Koeber,Hans-Hermann Kluenemann,Reinhold Waimer,Anton Koestlbacher,Markus Wittmann,Regina Brandl,Anett Doerfelt,Tatjana Jahner,D Melchner,Ekkehard Haen +9 more
TL;DR: Application of the method to patient serum samples discovered that concentrations suggested as "therapeutic" in the literature may only be reached either by high, off-label dosages or by utilization of inhibitory metabolic effects of the comedication.