Institution
University Hospital Regensburg
Healthcare•Regensburg, Germany•
About: University Hospital Regensburg is a healthcare organization based out in Regensburg, Germany. It is known for research contribution in the topics: Transplantation & Medicine. The organization has 3352 authors who have published 5164 publications receiving 136681 citations.
Topics: Transplantation, Medicine, Population, Immune system, Inflammation
Papers published on a yearly basis
Papers
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University of Copenhagen1, University Hospital Regensburg2, University of Birmingham3, University of North Carolina at Chapel Hill4, Harvard University5, Aarhus University6, University of Edinburgh7, Lawrence Berkeley National Laboratory8, European Bioinformatics Institute9, Karolinska Institutet10, VU University Medical Center11
TL;DR: It is shown that enhancers share properties with CpG-poor messenger RNA promoters but produce bidirectional, exosome-sensitive, relatively short unspliced RNAs, the generation of which is strongly related to enhancer activity.
Abstract: Enhancers control the correct temporal and cell-type-specific activation of gene expression in multicellular eukaryotes. Knowing their properties, regulatory activity and targets is crucial to understand the regulation of differentiation and homeostasis. Here we use the FANTOM5 panel of samples, covering the majority of human tissues and cell types, to produce an atlas of active, in vivo-transcribed enhancers. We show that enhancers share properties with CpG-poor messenger RNA promoters but produce bidirectional, exosome-sensitive, relatively short unspliced RNAs, the generation of which is strongly related to enhancer activity. The atlas is used to compare regulatory programs between different cells at unprecedented depth, to identify disease-associated regulatory single nucleotide polymorphisms, and to classify cell-type-specific and ubiquitous enhancers. We further explore the utility of enhancer redundancy, which explains gene expression strength rather than expression patterns. The online FANTOM5 enhancer atlas represents a unique resource for studies on cell-type-specific enhancers and gene regulation.
2,260 citations
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TL;DR: The understanding of the risk factors and causes of GHVD, the cellular and cytokine networks implicated in its pathophysiology, and current strategies to prevent and treat the disease are reviewed.
2,083 citations
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TL;DR: The ELITE II Losartan Heart Failure Survival Study as discussed by the authors showed an association between the angiotensin II antagonist losartan and an unexpected survival benefit in elderly heart-failure patients, compared with captopril, an ACE inhibitor.
1,862 citations
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TL;DR: This review reinforces the concept that estrogens have antiinflammatory but also proinflammatory roles depending on above-mentioned criteria and explains that a uniform concept as to the action of estrogens cannot be found for all inflammatory diseases due to the enormous variable responses of immune and repair systems.
Abstract: There is still an unresolved paradox with respect to the immunomodulating role of estrogens. On one side, we recognize inhibition of bone resorption and suppression of inflammation in several animal models of chronic inflammatory diseases. On the other hand, we realize the immunosupportive role of estrogens in trauma/sepsis and the proinflammatory effects in some chronic autoimmune diseases in humans. This review examines possible causes for this paradox. This review delineates how the effects of estrogens are dependent on criteria such as: 1) the immune stimulus (foreign antigens or autoantigens) and subsequent antigen-specific immune responses (e.g., T cell inhibited by estrogens vs. activation of B cell); 2) the cell types involved during different phases of the disease; 3) the target organ with its specific microenvironment; 4) timing of 17beta-estradiol administration in relation to the disease course (and the reproductive status of a woman); 5) the concentration of estrogens; 6) the variability in expression of estrogen receptor alpha and beta depending on the microenvironment and the cell type; and 7) intracellular metabolism of estrogens leading to important biologically active metabolites with quite different anti- and proinflammatory function. Also mentioned are systemic supersystems such as the hypothalamic-pituitary-adrenal axis, the sensory nervous system, and the sympathetic nervous system and how they are influenced by estrogens. This review reinforces the concept that estrogens have antiinflammatory but also proinflammatory roles depending on above-mentioned criteria. It also explains that a uniform concept as to the action of estrogens cannot be found for all inflammatory diseases due to the enormous variable responses of immune and repair systems.
1,486 citations
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TL;DR: Using mice infected with SARS-CoV, it is demonstrated that robust virus replication accompanied by delayed type I interferon (IFN-I) signaling orchestrates inflammatory responses and lung immunopathology with diminished survival and is identified as a potential therapeutic targets in patients infected with pathogenic coronavirus and perhaps other respiratory viruses.
1,231 citations
Authors
Showing all 3381 results
Name | H-index | Papers | Citations |
---|---|---|---|
Donald M. Bers | 118 | 570 | 52757 |
Thomas Bein | 109 | 677 | 42800 |
Jeanette Erdmann | 99 | 373 | 58482 |
Peter J. Neumann | 94 | 733 | 39294 |
Peter J. Oefner | 90 | 348 | 30729 |
Gerd Schmitz | 90 | 626 | 33170 |
Robert S. Negrin | 84 | 378 | 25179 |
Andreas Voss | 83 | 757 | 28426 |
Matthias Mack | 81 | 250 | 24814 |
Fabian J. Theis | 81 | 533 | 27851 |
Jürgen Schölmerich | 79 | 490 | 24354 |
Michael Landthaler | 77 | 551 | 22288 |
Jeffrey C. Rathmell | 76 | 211 | 28092 |
Reinhard Andreesen | 75 | 351 | 19588 |
Heinz Wiendl | 75 | 624 | 21229 |