Anette Duensing

TL;DR: It is shown that knock-down of p21 protein expression in murine myeloblasts can stimulate excessive centriole numbers in the presence of only one or two mature centrioles, and that aberrant centrosome numbers cannot solely be explained by polyploidization as suggested by previous studies.

TL;DR: There is overall a significant correlation between BRCA2 inactivation and a poor response rate to docetaxel, and the results suggest that a close oncological monitoring of patients with BRCa2 mutations for taxane resistance is warranted.

TL;DR: Indirubin-derived compounds that have been chemically modified to be inactive as kinase inhibitors still significantly reduced centrosome amplification, suggesting that these compounds are potentially useful for the chemoprevention of centrerosome-mediated cell division errors and malignant progression in neoplasms in which the AhR is overexpressed.

TL;DR: The antitumor effects of the pro‐apoptotic Bcl‐2/Bcl‐xL inhibitor ABT‐737 are examined alone and in combination with imatinib to enhance imatin ib‐induced cytotoxicity and overcome imatinIB‐resistance in GIST cells.

TL;DR: Prostate cancer cells with high nuclear AR-V7 protein expression can be detected in a substantial proportion of tumors at the time of radical prostatectomy and is associated with an unfavorable prognosis for BCR-free survival in a high-risk patient cohort including a subgroup of patients selected to receive adjuvant treatment.