H
Holger Sültmann
Researcher at German Cancer Research Center
Publications - 196
Citations - 12979
Holger Sültmann is an academic researcher from German Cancer Research Center. The author has contributed to research in topics: Prostate cancer & Cancer. The author has an hindex of 50, co-authored 177 publications receiving 11367 citations. Previous affiliations of Holger Sültmann include University of Göttingen & University of Hamburg.
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Variance stabilization applied to microarray data calibration and to the quantification of differential expression.
TL;DR: A statistical model for microarray gene expression data that comprises data calibration, the quantifying of differential expression, and the quantification of measurement error is introduced, and a difference statistic Deltah whose variance is approximately constant along the whole intensity range is derived.
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Hepatitis B and D Viruses Exploit Sodium Taurocholate Co-transporting Polypeptide for Species-Specific Entry into Hepatocytes
Yi Ni,Florian A. Lempp,Stefan Mehrle,Shirin Nkongolo,Christina Kaufman,Maria Fälth,Jan Stindt,Christian Königer,Michael Nassal,Ralf Kubitz,Holger Sültmann,Stephan Urban +11 more
TL;DR: Mapping of motifs in NTCPs have increased the understanding of the species specificities of HBV and HDV, and could lead to small animal models for studies of viral infection and replication.
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Circulating miRNAs are correlated with tumor progression in prostate cancer.
Jan C. Brase,Marc Johannes,Thorsten Schlomm,Maria Fälth,Alexander Haese,Thomas Steuber,Tim Beissbarth,Ruprecht Kuner,Holger Sültmann +8 more
TL;DR: Observations suggest that mi RNA‐375 and miRNA‐141 expression is enhanced in prostate cancer specimens and their release into the blood is further associated with advanced cancer disease.
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The Human let-7a-3 Locus Contains an Epigenetically Regulated MicroRNA Gene with Oncogenic Function
Bodo Brueckner,Carlo Stresemann,Ruprecht Kuner,Cora Mund,Tanja Musch,Michael Meister,Holger Sültmann,Frank Lyko +7 more
TL;DR: Let-7a-3 is identified as an epigenetically regulated mi RNA gene with oncogenic function and aberrant miRNA gene methylation might contribute to the human cancer epigenome and is suggested to be associated with a CpG island.
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Serum microRNAs as non-invasive biomarkers for cancer
TL;DR: Although several challenges remain to be addressed, circulating microRNAs have the potential to be useful for the diagnosis and prognosis of cancer diseases.