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Angela L. Man
Researcher at Norwich University
Publications - 26
Citations - 776
Angela L. Man is an academic researcher from Norwich University. The author has contributed to research in topics: Biology & Immune system. The author has an hindex of 11, co-authored 21 publications receiving 527 citations. Previous affiliations of Angela L. Man include University of Bristol & University of Siena.
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Journal ArticleDOI
Age-associated modifications of intestinal permeability and innate immunity in human small intestine
Angela L. Man,Eugenio Bertelli,Silvia Rentini,Marì Regoli,G. L. Briars,Mario Marini,Alastair J.M. Watson,Alastair J.M. Watson,Claudio Nicoletti +8 more
TL;DR: Assessment of inflammatory cytokines, barrier integrity and cytokine production in response to microbial challenges suggested that aging affects properties of the intestinal barrier likely to impact on age-associated disturbances, both locally and systemically.
Journal ArticleDOI
Faecal microbiota transplant from aged donor mice affects spatial learning and memory via modulating hippocampal synaptic plasticity- and neurotransmission-related proteins in young recipients.
Alfonsina D'Amato,Lorenzo Di Cesare Mannelli,Elena Lucarini,Angela L. Man,Gwénaëlle Le Gall,Jacopo Junio Valerio Branca,Carla Ghelardini,Amedeo Amedei,Eugenio Bertelli,Marì Regoli,Alessandra Pacini,Giulia Luciani,Pasquale Gallina,Annalisa Altera,Arjan Narbad,Massimo Gulisano,Lesley Hoyles,David Vauzour,Claudio Nicoletti +18 more
TL;DR: It is reported that faecal microbiota transplant from aged donors led to impaired spatial learning and memory in young adult recipients, whereas anxiety, explorative behaviour and locomotor activity remained unaffected, highlighting the paramount importance of the gut-brain axis in ageing.
Journal ArticleDOI
The impact of ageing on the intestinal epithelial barrier and immune system
TL;DR: The aim of this review is to summarise the impact of ageing on the intestinal immune system, including the gut epithelium and other components of the intestinal barrier that maintain intestinal immune homeostasis and shape antigen-specific immune responses.
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Improving M cell mediated transport across mucosal barriers: do certain bacteria hold the keys?
TL;DR: Novel information on the interactions between bacteria and FAE have come to light that unveil further the complex cross‐talk taking place at mucosal interfaces between bacteria, epithelial cells and the immune system and which are central to the formation and function of M cells.
Posted ContentDOI
Faecal microbiota transplant from aged donor mice affects spatial learning and memory via modulating hippocampal synaptic plasticity- and neurotransmission-related proteins in young recipients
Alfonsina D'Amato,Lorenzo Di Cesare-Mannelli,Elena Lucarini,Angela L. Man,Gwénaëlle Le Gall,Jacopo Junio Valerio Branca,Carla Ghelardini,Amedeo Amedei,Eugenio Bertelli,Marì Regoli,Alessandra Pacini,Giulia Luciani,Pasquale Gallina,Annalisa Altera,Arjan Narbad,Massimo Gulisano,Lesley Hoyles,David Vauzour,Claudio Nicoletti +18 more
TL;DR: A direct effect of the age-associated shifts of the microbiota on protein expression and key functions of the central nervous system is demonstrated in young adult recipients of faecal microbiota transplant, highlighting the paramount importance of the gut-brain axis in ageing.