A
Angela R. Woodward
Researcher at Durham University
Publications - 2
Citations - 183
Angela R. Woodward is an academic researcher from Durham University. The author has contributed to research in topics: Prodrug & Indole test. The author has an hindex of 2, co-authored 2 publications receiving 168 citations.
Papers
More filters
Journal ArticleDOI
Discovery of novel 2-aminobenzamide inhibitors of heat shock protein 90 as potent, selective and orally active antitumor agents.
Kenneth He Huang,James Marvin Veal,Patrick Fadden,John W. Rice,Jeron Eaves,Jon-Paul Strachan,Amy F. Barabasz,Briana Foley,Barta Thomas E,Wei Ma,Melanie Silinski,Mei Hu,Jeffrey M. Partridge,Anisa Scott,Laura G. Dubois,Tiffany Freed,Paul M. Steed,Andy J. Ommen,Emilie D. Smith,Philip F. Hughes,Angela R. Woodward,Hanson Gunnar J,W. Stephen Mccall,Christopher John Markworth,Lindsay Hinkley,Matthew Jenks,Geng Lifeng,Meredith Lewis,James C. Otto,Bert Pronk,Katleen Verleysen,Steven E. Hall +31 more
TL;DR: A novel class of heat shock protein 90 (Hsp90) inhibitors was developed from an unbiased screen to identify protein targets for a diverse compound library, and optimized analogues exhibited nanomolar antiproliferative activity across multiple cancer cell lines.
Patent
Tetrahydroindole and tetrahydroindazole derivatives
Kenneth He Huang,Andy J. Ommen,Thomas E. Barta,Philip Hughes,James Marvin Veal,Wei Ma,Emilie D. Smith,Angela R. Woodward,W. Stephen Mccall +8 more
TL;DR: In this paper, the authors provide indole and indazole compounds of Formula (I) or pharmaceutically acceptable salts thereof which are useful for treating and/or preventing diseases and disorders ameliorated by the inhibition of Heat-Shock Protein 90.