L
Lindsay Hinkley
Researcher at Durham University
Publications - 8
Citations - 415
Lindsay Hinkley is an academic researcher from Durham University. The author has contributed to research in topics: Prodrug & Biological target. The author has an hindex of 5, co-authored 8 publications receiving 394 citations.
Papers
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Journal ArticleDOI
Discovery of novel 2-aminobenzamide inhibitors of heat shock protein 90 as potent, selective and orally active antitumor agents.
Kenneth He Huang,James Marvin Veal,Patrick Fadden,John W. Rice,Jeron Eaves,Jon-Paul Strachan,Amy F. Barabasz,Briana Foley,Barta Thomas E,Wei Ma,Melanie Silinski,Mei Hu,Jeffrey M. Partridge,Anisa Scott,Laura G. Dubois,Tiffany Freed,Paul M. Steed,Andy J. Ommen,Emilie D. Smith,Philip F. Hughes,Angela R. Woodward,Hanson Gunnar J,W. Stephen Mccall,Christopher John Markworth,Lindsay Hinkley,Matthew Jenks,Geng Lifeng,Meredith Lewis,James C. Otto,Bert Pronk,Katleen Verleysen,Steven E. Hall +31 more
TL;DR: A novel class of heat shock protein 90 (Hsp90) inhibitors was developed from an unbiased screen to identify protein targets for a diverse compound library, and optimized analogues exhibited nanomolar antiproliferative activity across multiple cancer cell lines.
Journal ArticleDOI
Application of Chemoproteomics to Drug Discovery: Identification of a Clinical Candidate Targeting Hsp90.
Patrick Fadden,Kenneth He Huang,James Marvin Veal,Paul M. Steed,Amy F. Barabasz,Briana Foley,Mei Hu,Jeffrey M. Partridge,John W. Rice,Anisa Scott,Laura G. Dubois,Tiffany Freed,Melanie Silinski,Barta Thomas E,Philip F. Hughes,Andy J. Ommen,Wei Ma,Emilie D. Smith,Angela Woodward Spangenberg,Jeron Eaves,Hanson Gunnar J,Lindsay Hinkley,Matthew Jenks,Meredith Lewis,James C. Otto,Gijsbertus J. Pronk,Katleen Verleysen,Timothy A.J. Haystead,Steven E. Hall +28 more
TL;DR: The chemoproteomics-based approach, which also provides broad target selectivity information, was used to drive the identification of a potent and orally active Hsp90 inhibitor, SNX-5422, which is currently in phase 1 clinical studies.
Patent
Tetrahydroindolone and tetrahydroindazolone derivatives
Kenneth He Huang,Jeron Eaves,James Marvin Veal,Thomas E. Barta,Geng Lifeng,Lindsay Hinkley,Hanson Gunnar J +6 more
TL;DR: In this paper, compounds and pharmaceutically acceptable salts of Formula (I) are defined as A, Q1, Q2, Q3, R31, and R41.
Patent
Benzene, pyridine, and pyridazine derivatives
Kenneth He Huang,Jeron Eaves,Hanson Gunnar J,James Marvin Veal,Barta Thomas E,Geng Lifeng,Lindsay Hinkley +6 more
TL;DR: In this article, compounds and pharmaceutically acceptable salts of Formula (I) were defined and defined as useful in the treatment of diseases and conditions related to cell proliferation, such as cancer, inflammation, arthritis, angiogenesis, or the like.
Patent
Substituted quinoline and quinazoline inhibitors of quinone reductase 2
TL;DR: In this article, a method for inhibiting quinone reductase 2 (QR2) was proposed for the treatment of malaria and autoimmune diseases using quinoline and quinazoline derivatives.