J
James C. Otto
Researcher at Duke University
Publications - 32
Citations - 2032
James C. Otto is an academic researcher from Duke University. The author has contributed to research in topics: Inositol phosphate & Inositol. The author has an hindex of 19, co-authored 31 publications receiving 1906 citations. Previous affiliations of James C. Otto include Howard Hughes Medical Institute & Durham University.
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Journal ArticleDOI
A conserved family of enzymes that phosphorylate inositol hexakisphosphate
Sashidhar Mulugu,Sashidhar Mulugu,Wenli Bai,Wenli Bai,Peter C. Fridy,Peter C. Fridy,Robert J. Bastidas,Robert J. Bastidas,James C. Otto,James C. Otto,D. Eric Dollins,D. Eric Dollins,Timothy A.J. Haystead,Timothy A.J. Haystead,Anthony A. Ribeiro,Anthony A. Ribeiro,John D. York,John D. York +17 more
TL;DR: A previously uncharacterized class of inositol pyrophosphate synthase is reported and it is identical to yeast Vip1 and Asp1 proteins, regulators of actin-related protein-2/3 (ARP 2/3) complexes.
Journal ArticleDOI
Disruption of the Mouse Rce1 Gene Results in Defective Ras Processing and Mislocalization of Ras within Cells
Edward Kim,Patricia Ambroziak,James C. Otto,Brigit R. Taylor,Matthew N. Ashby,Kevin Shannon,Patrick J. Casey,Stephen G. Young +7 more
TL;DR: These studies indicate that Rce1 is responsible for the endoproteolytic processing of the Ras proteins in mammals and suggest a broad role for this gene in processing other prenylated CAAX proteins.
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Cloning and characterization of a mammalian prenyl protein-specific protease.
TL;DR: The identification of a portion of a putative human homologue of RCE1 (hRCE1) was identified in a human expressed sequence tag data base, and the corresponding cDNA was cloned, suggesting that they play a major role in the processing of CAAX-type prenylated proteins.
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Discovery of novel 2-aminobenzamide inhibitors of heat shock protein 90 as potent, selective and orally active antitumor agents.
Kenneth He Huang,James Marvin Veal,Patrick Fadden,John W. Rice,Jeron Eaves,Jon-Paul Strachan,Amy F. Barabasz,Briana Foley,Barta Thomas E,Wei Ma,Melanie Silinski,Mei Hu,Jeffrey M. Partridge,Anisa Scott,Laura G. Dubois,Tiffany Freed,Paul M. Steed,Andy J. Ommen,Emilie D. Smith,Philip F. Hughes,Angela R. Woodward,Hanson Gunnar J,W. Stephen Mccall,Christopher John Markworth,Lindsay Hinkley,Matthew Jenks,Geng Lifeng,Meredith Lewis,James C. Otto,Bert Pronk,Katleen Verleysen,Steven E. Hall +31 more
TL;DR: A novel class of heat shock protein 90 (Hsp90) inhibitors was developed from an unbiased screen to identify protein targets for a diverse compound library, and optimized analogues exhibited nanomolar antiproliferative activity across multiple cancer cell lines.
Journal ArticleDOI
Isoprenylcysteine Carboxyl Methyltransferase Deficiency in Mice
Martin O. Bergo,Gordon K. Leung,Gordon K. Leung,Patricia Ambroziak,James C. Otto,Patrick J. Casey,Anita Quintal Gomes,Miguel C. Seabra,Stephen G. Young,Stephen G. Young +9 more
TL;DR: IcmT deficiency caused a more severe phenotype than Rce1 deficiency, with virtually all of the knockout embryos (Icmt−/−) dying by mid-gestation, and Icmt appears to be the only enzyme participating in the carboxyl methylation of isoprenylated proteins.