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Angela T. S. Wyse
Researcher at Universidade Federal do Rio Grande do Sul
Publications - 396
Citations - 10156
Angela T. S. Wyse is an academic researcher from Universidade Federal do Rio Grande do Sul. The author has contributed to research in topics: Oxidative stress & Na+/K+-ATPase. The author has an hindex of 47, co-authored 380 publications receiving 9139 citations. Previous affiliations of Angela T. S. Wyse include University of Rio Grande & Universidade Luterana do Brasil.
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NTPDase and 5'-nucleotidase activities in physiological and disease conditions: new perspectives for human health.
TL;DR: Changes in ATP, ADP and AMP hydrolysis induced by inborn errors of metabolism, seizures and epilepsy are discussed in order to highlight the importance of these enzymes in the control of neuronal activity in pathological conditions.
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The role of oxidative damage in the neuropathology of organic acidurias: insights from animal studies.
TL;DR: This review addresses some of the recent developments obtained mainly from animal studies indicating oxidative damage as an important determinant of the neuropathophysiology of some organic acidurias, and shows that various organic acids are capable of inducing free radical generation and decreasing brain antioxidant defences.
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Differential Macrophage Activation Alters the Expression Profile of NTPDase and Ecto-5′-Nucleotidase
Rafael Fernandes Zanin,Elizandra Braganhol,Letícia Scussel Bergamin,Luis Felipe Campesato,Alfeu Zanotto Filho,José Cláudio Fonseca Moreira,Fernanda Bueno Morrone,Jean Sévigny,Maria Rosa Chitolina Schetinger,Angela T. S. Wyse,Ana Maria Oliveira Battastini +10 more
TL;DR: Changes in ectoenzyme activities might allow macrophages to adjust the outcome of the extracellular purinergic cascade in order to fine-tune their functions during the inflammatory set.
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Methylmalonate administration decreases Na+,K+-ATPase activity in cerebral cortex of rats.
Angela T. S. Wyse,Emilio L. Streck,Sonja Verginia Tamborena Barros,Ana Maria Brusque,Alexandra I. Zugno,Moacir Wajner +5 more
TL;DR: Na+, K+-ATPase and Mg2+- ATPase activities were determined in the synaptic plasma membranes from cerebral cortex of rats, and MMA at final concentrations ranging from 0.1 to 2.0 mM had no in vitro effect on these enzyme activities.
Journal ArticleDOI
Inhibition of the mitochondrial respiratory chain complex activities in rat cerebral cortex by methylmalonic acid.
Ana Maria Brusque,R. Borba Rosa,Patrícia Fernanda Schuck,Karina Borges Dalcin,César A. J. Ribeiro,Cleide Goncalves da Silva,Clovis Milton Duval Wannmacher,Carlos Severo Dutra-Filho,Angela T. S. Wyse,P Briones,Moacir Wajner +10 more
TL;DR: A deficit of brain energy production might explain some of the neurological abnormalities found in patients with methylmalonic acidemia (MMAemia) and be responsible for the lactic acidemia/aciduria identified in some of them.