C
Cleide Goncalves da Silva
Researcher at Beth Israel Deaconess Medical Center
Publications - 30
Citations - 1466
Cleide Goncalves da Silva is an academic researcher from Beth Israel Deaconess Medical Center. The author has contributed to research in topics: Inflammation & Mitochondrion. The author has an hindex of 21, co-authored 30 publications receiving 1310 citations. Previous affiliations of Cleide Goncalves da Silva include Universidade Federal do Rio Grande do Sul.
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Journal ArticleDOI
The P2X7 Receptor in Inflammatory Diseases: Angel or Demon?
TL;DR: In neuroinflammatory and neurodegenerative diseases, P2X7 upregulation and function appears to contribute to disease progression, and is highlighted as a potential target to treat inflammatory related diseases.
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Inhibition of the mitochondrial respiratory chain complex activities in rat cerebral cortex by methylmalonic acid.
Ana Maria Brusque,R. Borba Rosa,Patrícia Fernanda Schuck,Karina Borges Dalcin,César A. J. Ribeiro,Cleide Goncalves da Silva,Clovis Milton Duval Wannmacher,Carlos Severo Dutra-Filho,Angela T. S. Wyse,P Briones,Moacir Wajner +10 more
TL;DR: A deficit of brain energy production might explain some of the neurological abnormalities found in patients with methylmalonic acidemia (MMAemia) and be responsible for the lactic acidemia/aciduria identified in some of them.
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Mitochondrial energy metabolism is markedly impaired by d-2-hydroxyglutaric acid in rat tissues
Alexandra Latini,Cleide Goncalves da Silva,Gustavo da Costa Ferreira,Patrícia Fernanda Schuck,Karina Scussiato,João José Freitas Sarkis,Carlos Severo Dutra Filho,Angela T. S. Wyse,Clovis Milton Duval Wannmacher,Moacir Wajner,Moacir Wajner +10 more
TL;DR: It is presumed that impairment of energy metabolism may contribute to the understanding of the clinical features mainly of patients affected by DHGA.
Journal ArticleDOI
Mechanism of Purinergic Activation of Endothelial Nitric Oxide Synthase in Endothelial Cells
TL;DR: It is indicated that extracellular nucleotide–mediated eNOS phosphorylation is calcium and protein kinase C&dgr; dependent, and this newly identified signaling pathway opens new therapeutic avenues for the treatment of endothelial dysfunction.
Journal ArticleDOI
Inhibition of cytochrome c oxidase activity in rat cerebral cortex and human skeletal muscle by D-2-hydroxyglutaric acid in vitro.
Cleide Goncalves da Silva,César A. J. Ribeiro,Guilhian Leipnitz,Carlos Severo Dutra-Filho,Ângela Terezinha de Souza Wyse,Clovis Milton Duval Wannmacher,João José Freitas Sarkis,Cornelis Jakobs,Moacir Wajner +8 more
TL;DR: The results suggest that the strong inhibition of cytochrome c oxidase activity by increased levels of DGA could be related to the neurodegeneration of patients affected by D-2-hydroxyglutaric aciduria.