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Angelica M. Merlot
Researcher at University of Sydney
Publications - 31
Citations - 7418
Angelica M. Merlot is an academic researcher from University of Sydney. The author has contributed to research in topics: Cancer cell & Cancer. The author has an hindex of 21, co-authored 31 publications receiving 6527 citations. Previous affiliations of Angelica M. Merlot include University of New South Wales.
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Journal ArticleDOI
Potentiating the cellular targeting and anti-tumor activity of Dp44mT via binding to human serum albumin: two saturable mechanisms of Dp44mT uptake by cells.
Angelica M. Merlot,Sumit Sahni,Darius J.R. Lane,Ashleigh M. Fordham,Namfon Pantarat,David E. Hibbs,Vera Richardson,Munikumar Reddy Doddareddy,Jennifer Ong,Michael L.-H. Huang,Des R. Richardson,Danuta S. Kalinowski +11 more
TL;DR: Interestingly, HSA decreased Bp4eT and PIH uptake, potentially due to its high affinity for the ligands, and markedly stimulated Dp44mT uptake by cells, with two saturated uptake mechanisms identified.
Journal ArticleDOI
Cellular uptake of the antitumor agent Dp44mT occurs via a carrier/receptor-mediated mechanism.
Angelica M. Merlot,Namfon Pantarat,Sharleen V. Menezes,Sumit Sahni,Des R. Richardson,Danuta S. Kalinowski +5 more
TL;DR: Findings examining the mechanism of Dp44mT uptake and its distribution and excretion have clinical implications for its bioavailability and uptake in vivo.
Journal ArticleDOI
Membrane Transport and Intracellular Sequestration of Novel Thiosemicarbazone Chelators for the Treatment of Cancer
TL;DR: It can be concluded that 2-benzoylpyridine 4-ethyl-3-thiosemicarbazone, also known as Bp4eT, more effectively permeated the cell membrane and evaded rapid efflux in contrast to pyridoxal isonicotinoyl hydrazone, which exhibits low anticancer activity.
Journal ArticleDOI
Exploiting Cancer Metal Metabolism using Anti-Cancer Metal- Binding Agents.
Angelica M. Merlot,Danuta S. Kalinowski,Zaklina Kovacevic,Patric J. Jansson,Sumit Sahni,Michael L.-H. Huang,Darius J.R. Lane,Hiu Chuen Lok,Des R. Richardson +8 more
TL;DR: The role and changes in homeostasis of metals in cancer is highlighted and the pre-clinical development and clinical assessment of metal ion-binding agents, namely, thiosemicarbazones, as antitumor agents are emphasized.
Journal ArticleDOI
Making a case for albumin – a highly promising drug-delivery system.
Angelica M. Merlot,Danuta S. Kalinowski,Zaklina Kovacevic,Patric J. Jansson,Darius J.R. Lane,Michael L.-H. Huang,Sumit Sahni,Des R. Richardson +7 more
TL;DR: Since those pioneering days, parenteral administration of albumin has been indicated for shock, hypovolemia, hypoalbuminemia, burns, acute respiratory distress, cardiopulmonary bypass surgery and acute liver failure.