Angelino Calderone

TL;DR: The biological role of nestin(+)-cells during physiological and pathological remodeling of the heart and vasculature is highlighted and the phenotypic advantage attributed to the intermediate filament protein is discussed.

TL;DR: PBI-4050 reduces PH and RVH in HFrEF by decreasing lung fibrosis and remodelling and recovers RV function, a novel promising therapy for targeting lung remodelling in group II PH.

TL;DR: It is shown that a sub‐population of cardiac resident nestin(+) cells can further differentiate to a neuronal‐like fate in vivo following myocardial infarction and directly contributed to neural remodelling of the peri‐infarct/infarCT region of the ischemically damaged rat heart via the de novo synthesis of neurofilament‐M fibres.

TL;DR: Nestin expressed by pre‐existing cardiomyocytes following ischemic damage recapitulated in part an embryonic trait and may provide the requisite phenotype to initiate cell cycle re‐entry, but the overt activation of the p38 MAPK pathway post‐MI may in part limit the appearance and inhibit the cell cycleRe‐entry of nestin(+)‐cardiomyocyte.

TL;DR: Hyperglycaemia-mediated nestin downregulation and the concomitant reduction of cycling vascular smooth muscle cells represent early markers of vascular disease in experimental type I diabetes.