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Angelo A. Manfredi
Researcher at Vita-Salute San Raffaele University
Publications - 286
Citations - 24292
Angelo A. Manfredi is an academic researcher from Vita-Salute San Raffaele University. The author has contributed to research in topics: Inflammation & Immune system. The author has an hindex of 66, co-authored 272 publications receiving 20833 citations. Previous affiliations of Angelo A. Manfredi include Mario Negri Institute for Pharmacological Research & University of Milan.
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Bet on NETs! Or on How to Translate Basic Science into Clinical Practice.
TL;DR: Activation of the autophagic pathway is intermingled with NET generation and sustains the metabolic requirements of the extensive intracellular vesicular formation, transport, and fusion associated withNET generation.
Journal Article
Apoptosis and systemic autoimmunity: the dendritic cell connection.
TL;DR: Some of the constrains regulating the access of dying cells' antigens to DCs, as well as censorship mechanisms that prevent their maturation and the full explication of their antigen presenting function are discussed.
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Exacerbation of Murine Experimental Autoimmune Myositis by Toll-Like Receptor 7/8.
Clara Sciorati,Antonella Monno,Maria Giulia Doglio,Elena Rigamonti,Dana P. Ascherman,Angelo A. Manfredi,Patrizia Rovere-Querini +6 more
TL;DR: Toll‐like receptor 7 (TLR‐7), TLR‐8, and interferon (IFN)–induced genes are expressed in patients with idiopathic inflammatory myositis and their activation influences the natural history of the disease.
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Anti-inflammatory action of apoptotic cells in patients with acute coronary syndromes.
Luca A. Ferri,Norma Maugeri,Patrizia Rovere-Querini,Alice Calabrese,Enrico Ammirati,Domenico Cianflone,Attilio Maseri,Angelo A. Manfredi +7 more
TL;DR: Patients with acute coronary syndromes and low circulating C-reactive protein levels are more sensitive to the anti-inflammatory action of apoptotic cells: this suggests the existence of an enhanced anti- inflammatory feedback circuit, which could contribute to protect from plaque instability.
Journal Article
Inhibition of Caspases Maintains the Antineoplastic Function of γδ T Cells Repeatedly Challenged with Lymphoma Cells
Marina Ferrarini,Giuseppe Consogno,Patrizia Rovere,Clara Sciorati,Lorenzo Dagna,Davide Resta,Claudio Rugarli,Angelo A. Manfredi +7 more
TL;DR: It is shown that γδ T cells, a model for the study of activation-induced apoptosis, activate on repeated in vitro antigen-recognition caspase 3 and 8 and dramatically down-regulate their cytotoxic and secretory function.