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Angelo A. Manfredi
Researcher at Vita-Salute San Raffaele University
Publications - 286
Citations - 24292
Angelo A. Manfredi is an academic researcher from Vita-Salute San Raffaele University. The author has contributed to research in topics: Inflammation & Immune system. The author has an hindex of 66, co-authored 272 publications receiving 20833 citations. Previous affiliations of Angelo A. Manfredi include Mario Negri Institute for Pharmacological Research & University of Milan.
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Journal ArticleDOI
Are atopy and eosinophilic bronchial inflammation associated with relapsing forms of chronic rhinosinusitis with nasal polyps
Mona-Rita Yacoub,Matteo Trimarchi,George Cremona,Sara Dal Farra,Giuseppe A. Ramirez,Valentina Canti,Emanuel Della Torre,Mattia Baldini,Patrizia Pignatti,Mario Bussi,Maria Grazia Sabbadini,Angelo A. Manfredi,Giselda Colombo +12 more
TL;DR: Atopy, severe asthma, bronchial inflammation, NSAIDs hypersensitivity and high level of total IgE are possible useful prognostic factors for the proneness to relapse after FESS and the role of allergy in CRSwNP pathogenesis should be given deeper consideration.
Journal ArticleDOI
High blood levels of chromogranin A in giant cell arteritis identify patients refractory to corticosteroid treatment.
G. Di Comite,P Previtali,Carlo Maria Rossi,Giacomo Dell'Antonio,Patrizia Rovere-Querini,Luisa Praderio,Lorenzo Dagna,Angelo Corti,Claudio Doglioni,Attilio Maseri,Maria Grazia Sabbadini,Angelo A. Manfredi +11 more
TL;DR: Giant cell arteritis rapidly responds to high-dose corticosteroids, however, smouldering arterial inflammation can persist despite the absence of symptoms and altered acute phase reactants, and Chromogranin A in particular is a candidate marker linking neurogenic inflammation and vascular inflammation.
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T cells in myasthenia gravis specific for embryonic acetylcholine receptor.
TL;DR: In this paper, propagation from the blood of MG patients of T helper (T H ) cell lines specific for human embryonic AChR, by cycles of stimulation with a pool of synthetic peptides corresponding to the complete sequence of the γ subunit (γ pool), was reported.
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Leukocytes recruited by tumor-derived HMGB1 sustain peritoneal carcinomatosis
Lucia Cottone,Annalisa Capobianco,Chiara Gualteroni,Antonia Monno,Isabella Raccagni,Silvia Valtorta,Tamara Canu,Tiziano Di Tomaso,Angelo Lombardo,Antonio Esposito,Rosa Maria Moresco,Alessandro Del Maschio,Luigi Naldini,Patrizia Rovere-Querini,Marco Bianchi,Angelo A. Manfredi +15 more
TL;DR: These findings provide a preclinical proof of principle that strategies based on preventing HMGB1-driven recruitment of leukocytes could be used for treating peritoneal carcinomatosis.
Journal ArticleDOI
Chromogranin-A production and fragmentation in patients with Takayasu arteritis
Enrico Tombetti,Barbara Colombo,Maria Chiara Di Chio,Silvia Sartorelli,Maurizio Papa,A. Salerno,Enrica Bozzolo,Elisabetta Tombolini,Giulia Benedetti,Claudia Godi,Chiara Lanzani,Patrizia Rovere-Querini,Alessandro Del Maschio,Alessandro Ambrosi,Francesco De Cobelli,Maria Grazia Sabbadini,Elena Baldissera,Angelo Corti,Angelo A. Manfredi +18 more
TL;DR: The plasma levels of CgA fragments are markedly increased in TA as a consequence of disease- and therapy-related variables and it is advisable to limit the therapeutic prescriptions that might influence C gA-derived peptide levels to clearly agreed medical indications until further data become available.