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Aniek Janssen
Researcher at Utrecht University
Publications - 18
Citations - 2012
Aniek Janssen is an academic researcher from Utrecht University. The author has contributed to research in topics: Heterochromatin & Chromosome instability. The author has an hindex of 14, co-authored 18 publications receiving 1695 citations. Previous affiliations of Aniek Janssen include Lawrence Berkeley National Laboratory & Netherlands Cancer Institute.
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Chromosome Segregation Errors as a Cause of DNA Damage and Structural Chromosome Aberrations
TL;DR: The data show that segregation errors can cause translocations and provide insights into the role of whole-chromosome instability in tumorigenesis and show that chromosomes that missegregate can lead to unbalanced translocations in the daughter cells.
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Heterochromatin: Guardian of the Genome
TL;DR: It is proposed that more comprehensive analyses of heterochromatin roles in tumorigenesis will be integral to future innovations in cancer treatment and the importance of its maintenance for genome integrity is discussed.
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Elevating the frequency of chromosome mis-segregation as a strategy to kill tumor cells
TL;DR: Targeting the mitotic checkpoint and chromosome alignment simultaneously may selectively kill tumor cells by enhancing chromosome mis-segregations.
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Kif15 Cooperates with Eg5 to Promote Bipolar Spindle Assembly
Marvin E. Tanenbaum,Libor Macůrek,Aniek Janssen,Erica F. Geers,Mónica Álvarez-Fernández,René H. Medema +5 more
TL;DR: It is shown that, similar to Eg5, Kif15 can drive centrosome separation during bipolar spindle assembly, and this activity depends on its interaction with the microtubule-associated protein TPX2, indicating that a Kif 15-TPX2 complex promotes centrosomes separation.
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Mitosis as an anti-cancer target.
Aniek Janssen,René H. Medema +1 more
TL;DR: This review deals with the different strategies that are currently considered to perturb mitotic progression in the treatment of cancer.