L
Libor Macůrek
Researcher at Utrecht University
Publications - 10
Citations - 1328
Libor Macůrek is an academic researcher from Utrecht University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 5, co-authored 5 publications receiving 1224 citations.
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Journal ArticleDOI
Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery
Libor Macůrek,Arne Lindqvist,Daniel Lim,Michael A. Lampson,Rob Klompmaker,Raimundo Freire,Christophe Clouin,Stephen S. Taylor,Michael B. Yaffe,René H. Medema +9 more
TL;DR: It is demonstrated that the initial activation of PLK1 is a primary function of aurora A, and that Bora/aurora-A-dependent phosphorylation is a prerequisite for PLK 1 to promote mitotic entry after a checkpoint-dependent arrest.
Journal ArticleDOI
Kif15 Cooperates with Eg5 to Promote Bipolar Spindle Assembly
Marvin E. Tanenbaum,Libor Macůrek,Aniek Janssen,Erica F. Geers,Mónica Álvarez-Fernández,René H. Medema +5 more
TL;DR: It is shown that, similar to Eg5, Kif15 can drive centrosome separation during bipolar spindle assembly, and this activity depends on its interaction with the microtubule-associated protein TPX2, indicating that a Kif 15-TPX2 complex promotes centrosomes separation.
Journal ArticleDOI
Dynein, Lis1 and CLIP-170 counteract Eg5-dependent centrosome separation during bipolar spindle assembly.
TL;DR: Results suggest that complexes of dynein, Lis1 and CLIP‐170 crosslink and slide microtubules within the spindle, thereby producing an inward force that pulls centrosomes together.
Journal ArticleDOI
Wip1 phosphatase is associated with chromatin and dephosphorylates |[gamma]|H2AX to promote checkpoint inhibition
TL;DR: Wip1 has an essential role in dephosphorylation of γ-H2AX to silence the checkpoint and restore chromatin structure once DNA damage is repaired.
Journal ArticleDOI
Bora and Aurora-A continue to activate Plk1 in mitosis
Wytse Bruinsma,Wytse Bruinsma,Libor Macůrek,Raimundo Freire,Arne Lindqvist,Arne Lindqvist,René H. Medema,René H. Medema +7 more
TL;DR: It is found that once Plk1 is activated, minimal amounts of the Bora–Aurora-A complex are sufficient to sustain Plk 1 activity, which provides a cell with robust PlK1 activity once it has committed to mitosis.