R
René H. Medema
Researcher at Netherlands Cancer Institute
Publications - 267
Citations - 35087
René H. Medema is an academic researcher from Netherlands Cancer Institute. The author has contributed to research in topics: Cell cycle & Mitosis. The author has an hindex of 91, co-authored 258 publications receiving 32321 citations. Previous affiliations of René H. Medema include Imperial College London & Leiden University.
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Journal ArticleDOI
The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells.
Marc van de Wetering,Elena Sancho,Cornelis Verweij,Wim de Lau,Irma Oving,Adam Hurlstone,Karin van der Horn,Eduard Batlle,Damien Coudreuse,Anna-Pavlina G. Haramis,Menno Tjon-Pon-Fong,Petra Moerer,Maaike van den Born,Gwen Soete,Steven T. Pals,Martin Eilers,René H. Medema,Hans Clevers +17 more
TL;DR: The β-catenin/TCF-4 complex constitutes the master switch that controls proliferation versus differentiation in healthy and malignant intestinal epithelial cells.
Journal ArticleDOI
Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress
Geert J. P. L. Kops,Tobias B. Dansen,Paulien E. Polderman,Ingrid Saarloos,Karel W. A. Wirtz,Paul J. Coffer,Ting-T. Huang,Johannes L. Bos,René H. Medema,Boudewijn M.T. Burgering +9 more
TL;DR: It is shown that the PKB-regulated Forkhead transcription factor FOXO3a (also known as FKHR-L1) protects quiescent cells from oxidative stress by directly increasing their quantities of manganese superoxide dismutase messenger RNA and protein.
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AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1.
TL;DR: It is concluded that AFX-like proteins are involved in cell-cycle regulation and that inactivation of these proteins is an important step in oncogenic transformation.
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Cell death by mitotic catastrophe : a molecular definition
Maria Castedo,Jean-Luc Perfettini,Thomas Roumier,Karine Andreau,René H. Medema,Guido Kroemer +5 more
TL;DR: It is proposed that mitotic catastrophe results from a combination of deficient cell-cycle checkpoints and cellular damage and failure to arrest the cell cycle before or at mitosis triggers an attempt of aberrant chromosome segregation, which culminates in the activation of the apoptotic default pathway and cellular demise.
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Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1
TL;DR: It is reported that withdrawal of cytokine results in upregulation of Bimexpression concomitant with induction of the apoptotic program in lymphocytes, and a mechanism by which cytokines promote lymphocyte survival by inhibition of FKHR-L1, preventing Bim expression is proposed.